PMID- 29630934
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20181202
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 544
IP  - 1
DP  - 2018 Jun 10
TI  - Microparticle preparation by a propylene carbonate emulsification-extraction 
      method.
PG  - 213-221
LID - S0378-5173(18)30209-6 [pii]
LID - 10.1016/j.ijpharm.2018.03.062 [doi]
AB  - The use of various harmful organic solvents for microparticle formulations is 
      still widespread. Here, an alternative low toxicity solvent (propylene carbonate; 
      PC) is proposed for the preparation of poly(lactic-co-glycolic-acid) (PLGA) 
      microparticles. Based on the classical emulsification-solvent extraction 
      methodology, the use of PC offers the unique advantage of an additional solvent 
      extraction step using hydrolytic solvent cleavage during microparticle 
      preparation. Spherical, rough-surfaced microparticles were obtained with a volume 
      median diameter range from 20 to 60 microm. The residual PC content has been 
      identified to be the major factor for the solidification hindrance, leading to 
      polymeric Tg shifting due to a plasticizing effect. When applying the enhanced PC 
      extraction step, the residual PC content was lowered from 8.8% to 2.7% and 
      subsequently Tg values shifted from 8.2 to 37.7  degrees C. Additionally, the hydrolytic 
      solvent cleavage confirmed to have no impact on the PLGA stability. This method 
      presents a significant advancement towards replacing of conventional solvents in 
      the microparticle preparation due to more efficient solvent extraction.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Grizic, Daris
AU  - Grizic D
AD  - Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, 
      Gerhard-Domagk-Str. 3, 53121 Bonn, Germany. Electronic address: 
      daris.grizic@uni-bonn.de.
FAU - Lamprecht, Alf
AU  - Lamprecht A
AD  - Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, 
      Gerhard-Domagk-Str. 3, 53121 Bonn, Germany; PEPITE (EA4267), University of 
      Burgundy/Franche-Comte, Besancon, France. Electronic address: 
      alf.lamprecht@uni-bonn.de.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Emulsions)
RN  - 0 (Polysorbates)
RN  - 0 (Solvents)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8D08K3S51E (propylene carbonate)
RN  - T75W9911L6 (Propane)
SB  - IM
MH  - Drug Compounding
MH  - Emulsions
MH  - Lactic Acid/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polysorbates/*chemistry
MH  - Propane/*analogs & derivatives/chemistry
MH  - Solvents/*chemistry
OTO - NOTNLM
OT  - Enhanced solvent extraction
OT  - Microparticles
OT  - PLGA
OT  - Propylene carbonate
EDAT- 2018/04/10 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/04/10 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/03/16 00:00 [revised]
PHST- 2018/03/31 00:00 [accepted]
PHST- 2018/04/10 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/04/10 06:00 [entrez]
AID - S0378-5173(18)30209-6 [pii]
AID - 10.1016/j.ijpharm.2018.03.062 [doi]
PST - ppublish
SO  - Int J Pharm. 2018 Jun 10;544(1):213-221. doi: 10.1016/j.ijpharm.2018.03.062. Epub 
      2018 Apr 6.