PMID- 29631761
OWN - NLM
STAT- MEDLINE
DCOM- 20200122
LR  - 20200122
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 113
DP  - 2019 Sep
TI  - Rab22a: A novel regulator of immune functions.
PG  - 87-92
LID - S0161-5890(18)30107-X [pii]
LID - 10.1016/j.molimm.2018.03.028 [doi]
AB  - Dendritic cells (DCs) trigger CD8 + T cell responses after the internalization of 
      exogenous antigens in a process called cross-presentation. Multiple intracellular 
      transport events within the endocytic and secretory routes take place in order to 
      accomplish this fundamental immunological process. The endomembrane system can be 
      envisioned as a complex network of membrane domains coordinately working in the 
      fusion of organelles, the budding of vesicles and tubules, and modifying the 
      molecular composition of the limiting membranes. In this context of tightly 
      regulated and dynamic endomembrane transport, small GTPases of the Rab family 
      display a pivotal role by organizing membrane microdomains and defining specific 
      identities to the different intracellular compartments. In this review, we 
      synthesize and update the current knowledge about Rab22a, which has been involved 
      in several immune functions. In this way, we analyze the intracellular 
      localization of Rab22a and its important role in the endocytic recycling, 
      including its relevance during MHC-I trafficking, antigen cross-presentation by 
      DCs and the formation of T cell conjugates. We also describe how different 
      pathogenic microorganisms hijack Rab22a functions to achieve efficient infection 
      and intracellular survival strategies. Furthermore, we examine the oncogenic 
      properties of Rab22a and how its expression determines the progression of many 
      tumors. In summary, we highlight the role of Rab22a as a key effector of the 
      intracellular trafficking that could be exploited in future therapies to modulate 
      the immune system.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Mayorga, Luis S
AU  - Mayorga LS
AD  - Instituto de Histologia y Embriologia de Mendoza (IHEM, Universidad Nacional de 
      Cuyo, CONICET), Facultad de Ciencias Medicas and Facultad de Ciencias Exactas y 
      Naturales, Mendoza, Argentina. Electronic address: lmayorga@fcm.uncu.edu.ar.
FAU - Cebrian, Ignacio
AU  - Cebrian I
AD  - Instituto de Histologia y Embriologia de Mendoza (IHEM, Universidad Nacional de 
      Cuyo, CONICET), Facultad de Ciencias Medicas and Facultad de Ciencias Exactas y 
      Naturales, Mendoza, Argentina. Electronic address: 
      icebrian@mendoza-conicet.gob.ar.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180407
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Histocompatibility Antigens Class I)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Cross-Priming/immunology
MH  - Dendritic Cells/immunology
MH  - Endocytosis/immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Protein Transport/immunology
MH  - rab GTP-Binding Proteins/*immunology
OTO - NOTNLM
OT  - Antigen presentation
OT  - Intracellular trafficking
OT  - Pathogen infection
OT  - Rab22a
OT  - Small GTPases
OT  - Tumor growth
EDAT- 2018/04/11 06:00
MHDA- 2020/01/23 06:00
CRDT- 2018/04/11 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/03/29 00:00 [accepted]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2020/01/23 06:00 [medline]
PHST- 2018/04/11 06:00 [entrez]
AID - S0161-5890(18)30107-X [pii]
AID - 10.1016/j.molimm.2018.03.028 [doi]
PST - ppublish
SO  - Mol Immunol. 2019 Sep;113:87-92. doi: 10.1016/j.molimm.2018.03.028. Epub 2018 Apr 
      7.