PMID- 29632617
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 10
DP  - 2018
TI  - Sarcopenia: a chronic complication of type 2 diabetes mellitus.
PG  - 25
LID - 10.1186/s13098-018-0326-5 [doi]
LID - 25
AB  - BACKGROUND: Diabetics are at increased risk for impaired mobility and strength, 
      frequently related to the disease control. Sarcopenia is the reduction of muscle 
      mass associated with the decrease in muscle strength and/or performance, 
      resulting in worse morbidity in chronic diseases. METHODS: The objectives of this 
      paper was to assess the prevalence of sarcopenia in patients with type 2 diabetes 
      mellitus (T2DM) and determine its association with diabetes characteristics, 
      progression, and complications, as well as changes in bone mineral density. The 
      sample consisted of patients with T2DM followed at the outpatient clinics of the 
      Servico de Endocrinologia e Metabologia do Hospital de Clinicas da Universidade 
      Federal do Parana, from March to August 2016. Participants were men and women 
      above 18 years with T2DM diagnosed at least 1 year earlier. Individuals with 
      chronic diseases, users of any drug that modifies body composition, patients with 
      body mass index (BMI) > 35 or < 18 kg/m(2), and users of illicit drugs or 
      hormonal or nutritional supplementation were excluded. The selected patients 
      answered questionnaires about demographics, eating habits, and disease 
      characteristics, and performed a bone densitometry exam in a dual energy 
      absorptiometry (total body; spine and femur (total and neck)), a handgrip test by 
      manual dynamometer, and an evaluation of the abdominal circumference (AC). The 
      medical records were reviewed seeking diabetes data and laboratory test results. 
      Patients were matched for sex, age, and race with healthy controls [Control Group 
      (CG)]. The diagnosis of sarcopenia was conducted according to the criteria of the 
      Foundation for National Institute of Health. RESULTS: The final sample consisted 
      of 83 patients in the DG and 83 in the CG. The DG had higher BMI, WC, past 
      history of fractures and lower calcium and healthy diet intake (p < 0.005), 
      compared to the CG. The DG presented a higher frequency of abnormal BMD 
      (osteopenia in 45 (53%), and osteoporosis in 14 (19%)) and comorbidities than the 
      CG (p < 0.005). Pre-sarcopenia was not different between groups, but muscle 
      weakness was present in 25 diabetics (18 women) and only in 5 controls (4 men) 
      (p = 0.00036). Sarcopenia was diagnosed in 13 (16.2%) patients in the DG and 2 
      (2.4%) in the CG (p = 0.01168). Pre-sarcopenia and sarcopenia were associated 
      with altered BMD (p < 0.005), with no association with diabetes duration or 
      control. Body mass index and osteoporosis increased the likelihood to have 
      sarcopenia, but hypertension and healthy diet decreased it. CONCLUSION: The DG 
      had altered BMD associated with worse glycemic control, and a higher prevalence 
      of sarcopenia, suggesting the need to look for their presence in diabetics.
FAU - Trierweiler, Heloisa
AU  - Trierweiler H
AD  - 1Universidade Federal do Parana, Curitiba, PR Brazil. ISNI: 0000 0001 1941 472X. 
      GRID: grid.20736.30
FAU - Kisielewicz, Gabrielle
AU  - Kisielewicz G
AD  - 1Universidade Federal do Parana, Curitiba, PR Brazil. ISNI: 0000 0001 1941 472X. 
      GRID: grid.20736.30
FAU - Hoffmann Jonasson, Thaisa
AU  - Hoffmann Jonasson T
AD  - 2Internal Medicine, Universidade Federal do Parana, Curitiba, PR Brazil. ISNI: 
      0000 0001 1941 472X. GRID: grid.20736.30
FAU - Rasmussen Petterle, Ricardo
AU  - Rasmussen Petterle R
AD  - 3Statistics Department, Universidade Federal do Parana, Curitiba, PR Brazil. 
      ISNI: 0000 0001 1941 472X. GRID: grid.20736.30
FAU - Aguiar Moreira, Carolina
AU  - Aguiar Moreira C
AD  - 4Endocrine Division, Hospital de Clinicas da Universidade Federal do Parana 
      (SEMPR), Avenida Agostinho Leao Junior, 285, Alto da Gloria, Curitiba, PR 
      80030-110 Brazil. ISNI: 0000 0004 0502 3690. GRID: grid.411078.b
FAU - Zeghbi Cochenski Borba, Victoria
AU  - Zeghbi Cochenski Borba V
AD  - 4Endocrine Division, Hospital de Clinicas da Universidade Federal do Parana 
      (SEMPR), Avenida Agostinho Leao Junior, 285, Alto da Gloria, Curitiba, PR 
      80030-110 Brazil. ISNI: 0000 0004 0502 3690. GRID: grid.411078.b
LA  - eng
PT  - Journal Article
DEP - 20180403
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC5883537
OTO - NOTNLM
OT  - DXA
OT  - Muscle weakness
OT  - Pre-sarcopenia
OT  - Sarcopenia
OT  - Type 2 diabetes mellitus
EDAT- 2018/04/11 06:00
MHDA- 2018/04/11 06:01
PMCR- 2018/04/03
CRDT- 2018/04/11 06:00
PHST- 2018/03/03 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/04/11 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/04/11 06:01 [medline]
PHST- 2018/04/03 00:00 [pmc-release]
AID - 326 [pii]
AID - 10.1186/s13098-018-0326-5 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2018 Apr 3;10:25. doi: 10.1186/s13098-018-0326-5. 
      eCollection 2018.