PMID- 29632849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2228-7930 (Print)
IS  - 2228-7949 (Electronic)
IS  - 2228-7930 (Linking)
VI  - 8
IP  - 2
DP  - 2018 Mar-Apr
TI  - Doxorubicin-induced renal inflammation in rats: Protective role of Plantago 
      major.
PG  - 179-187
AB  - OBJECTIVE: The aim of the present study was to evaluate the possible protective 
      effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced 
      renal inflammation in rats. MATERIALS AND METHODS: 80 male albino rats were 
      randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, 
      Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR, and Ext1200+DXR. Duration 
      of the study was 35 days and DXR was intravenously injected on the 7(th) day of 
      the experiment. Tumor necrosis factor-alpha (TNF-alpha) production and monocyte 
      chemoattractant protein-1 (MCP-1) expression levels were assessed in the left 
      kidney. Serum creatinine concentration and osmolarity were determined on the 
      1(st), 14(th), 21(st), 28(th) and 35(th) days of the experiment. RESULTS: DXR 
      caused a significant increase in renal expression of MCP-1 and TNF-alpha production 
      compared to control animals. Administration of dexamethasone, vitamin E and P. 
      major extract significantly improved the expression of these inflammatory 
      mediators compared to DXR group. Compared to day 1 in DXR group, serum osmolarity 
      showed a significant increase on days 21, 28 and 35. Also, on these days, serum 
      osmolarity in DXR group was significantly higher than that on the same days in 
      control group. In Vit E+DXR and Ext 1200+DXR groups, there was no significant 
      changes in serum osmolarity among different days of the study. However, in these 
      groups, serum osmolarity on days 21, 28 and 35 showed a significant decrease 
      compared to the same days in DXR group. CONCLUSION: Present results suggest that 
      hydroethanolic extract of P. major protected renal tissue against DXR-induced 
      renal inflammation.
FAU - Entezari Heravi, Nazanin
AU  - Entezari Heravi N
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Hosseinian, Sara
AU  - Hosseinian S
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Co-first author.
FAU - Naji Ebrahimi Yazd, Zohreh
AU  - Naji Ebrahimi Yazd Z
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Shafei, Mohammad Naser
AU  - Shafei MN
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Ebrahimzadeh Bideskan, Alireza
AU  - Ebrahimzadeh Bideskan A
AD  - Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Shahraki, Samira
AU  - Shahraki S
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Samadi Noshahr, Zahra
AU  - Samadi Noshahr Z
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Motejadded, Fatemeh
AU  - Motejadded F
AD  - Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Beheshti, Farimah
AU  - Beheshti F
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mohebbati, Reza
AU  - Mohebbati R
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Parhizgar, Soghra
AU  - Parhizgar S
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Khajavi Rad, Abolfazl
AU  - Khajavi Rad A
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Phytomed
JT  - Avicenna journal of phytomedicine
JID - 101586220
PMC - PMC5885332
OTO - NOTNLM
OT  - Dexamethasone
OT  - Doxorubicin
OT  - Inflammation
OT  - Plantago major
OT  - Vitamin E
COIS- Authors declare no conflicts of interest.
EDAT- 2018/04/11 06:00
MHDA- 2018/04/11 06:01
PMCR- 2018/03/01
CRDT- 2018/04/11 06:00
PHST- 2018/04/11 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/04/11 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - AJP-8-179 [pii]
PST - ppublish
SO  - Avicenna J Phytomed. 2018 Mar-Apr;8(2):179-187.