PMID- 29633423
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 68
IP  - 6
DP  - 2018 Jun
TI  - MET amplification in endometrial cancers with clear-cell carcinoma components.
PG  - 367-373
LID - 10.1111/pin.12669 [doi]
AB  - Endometrial clear-cell carcinoma (ECC) is relatively rare. The expression of 
      diagnostic markers in this disease is similar to that of clear-cell carcinoma, 
      but the molecular carcinogenic events and therapeutic targets are mostly unknown. 
      MET gene amplification has been reported in various cancers, including ovarian 
      clear-cell carcinomas; however, the MET gene status has not previously been 
      examined in ECC. We performed real-time quantitative PCR (QPCR) and fluorescence 
      in situ hybridization (FISH) to analyze the MET gene statuses of 12 ECC cases. We 
      found MET amplifications in two cases (2/12; 16.7%) by both methods. Of the 12 
      cases, 9 were pure clear-cell carcinomas, and 3 were mixed types that included 
      mixes with endometrioid carcinomas in 2 cases, and the remaining case was a 
      heterologous-type carcinosarcoma that primarily consisted of a clear-cell 
      carcinoma component and a scarce chondrosarcoma component. Both of the MET 
      amplification cases were mixed; one contained endometrioid features, and the 
      other chondrosarcoma features. This is the first report to analyze the statuses 
      of the MET gene in ECCs, and the two mixed cases exhibited amplifications that 
      are shared with ovarian clear-cell carcinomas. Further studies with larger 
      numbers of cases are necessary to reveal the relationship between ECC and MET 
      amplification.
CI  - (c) 2018 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Obata, Yoshie
AU  - Obata Y
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
AD  - Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate 
      School of Medicine, 1-1-2 Daiko-Minami, Higashi-ku, Nagoya, 461-0047, Japan.
FAU - Yamashita, Yoriko
AU  - Yamashita Y
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
FAU - Takahashi, Koji
AU  - Takahashi K
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
AD  - Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate 
      School of Medicine, 1-1-2 Daiko-Minami, Higashi-ku, Nagoya, 461-0047, Japan.
FAU - Yasuda, Kouki
AU  - Yasuda K
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
AD  - Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate 
      School of Medicine, 1-1-2 Daiko-Minami, Higashi-ku, Nagoya, 461-0047, Japan.
FAU - Kato, Tomomi
AU  - Kato T
AD  - Saitama Medical University International Medical Center, 1397-1 Yamane, 
      Hidaka-shi, Saitama-ken, 350-1298, Japan.
FAU - Yasuda, Masanori
AU  - Yasuda M
AD  - Saitama Medical University International Medical Center, 1397-1 Yamane, 
      Hidaka-shi, Saitama-ken, 350-1298, Japan.
FAU - Naiki-Ito, Aya
AU  - Naiki-Ito A
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
FAU - Takahashi, Satoru
AU  - Takahashi S
AD  - Department of Experimental Pathology and Tumor Biology, Nagoya City University, 
      Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 
      467-8601, Japan.
FAU - Nagasaka, Tetsuro
AU  - Nagasaka T
AD  - Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate 
      School of Medicine, 1-1-2 Daiko-Minami, Higashi-ku, Nagoya, 461-0047, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - EC 2.7.10.1 (MET protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adenocarcinoma, Clear Cell/*genetics/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Endometrial Neoplasms/*genetics/*pathology
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-met/*genetics
OTO - NOTNLM
OT  - MET
OT  - clear-cell carcinoma of the endometrium
OT  - copy number assay
OT  - fluorescence in situ hybridization
OT  - gene amplification
OT  - real-time quantitative PCR
EDAT- 2018/04/11 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/04/11 06:00
PHST- 2017/06/09 00:00 [received]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/04/11 06:00 [entrez]
AID - 10.1111/pin.12669 [doi]
PST - ppublish
SO  - Pathol Int. 2018 Jun;68(6):367-373. doi: 10.1111/pin.12669. Epub 2018 Apr 6.