PMID- 29633887
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20220409
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Print)
IS  - 0886-022X (Linking)
VI  - 40
IP  - 1
DP  - 2018 Nov
TI  - Diabetic retinopathy may predict the renal outcomes of patients with diabetic 
      nephropathy.
PG  - 243-251
LID - 10.1080/0886022X.2018.1456453 [doi]
AB  - BACKGROUND: The patients with Type 2 diabetes mellitus (T2DM) and diabetic 
      retinopathy (DR) are prone to develop diabetic nephropathy (DN). In this study, 
      we aimed to clarify the relationship between DR and the progression of DN in 
      patients with T2DM. METHODS: In the cross-section study, 250 patients with T2DM 
      and biopsy-proven DN were divided into two groups: 130 in the DN without DR group 
      (DN group) and 120 in the DN + DR group. Logistic regression analysis was 
      performed to identify risk factors for DR. Of the above 250 patients, 141 were 
      recruited in the cohort study who received follow-up for at least 1 year and the 
      influence of DR on renal outcome was assessed using Cox regression. Renal outcome 
      was defined as the progression to end-stage renal disease (ESRD). RESULTS: In the 
      cross-section study, the severity of glomerular lesions (class IIb + III) and DM 
      history >10 years were significantly associated with the odds of DR when 
      adjusting for baseline proteinuria, hematuria, e-GFR, and interstitial 
      inflammation. In the cohort study, a multivariate COX analysis demonstrated that 
      the DR remained an independent risk factor for progression to ESRD when adjusting 
      for important clinical variables and pathological findings (p < .05). 
      CONCLUSIONS: These findings indicated that the severity of glomerular lesions was 
      significantly associated with DR and DR was an independent risk factor for the 
      renal outcomes in patients with DN, which suggested that DR may predict the renal 
      prognosis of patients with T2DM and DN.
FAU - Zhang, Junlin
AU  - Zhang J
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Wang, Yiting
AU  - Wang Y
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Li, Li
AU  - Li L
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Guo, Ruikun
AU  - Guo R
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Li, Hanyu
AU  - Li H
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Han, Qianqian
AU  - Han Q
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
FAU - Teng, Geer
AU  - Teng G
AD  - b Faculty of Social Development & Western China Development Studies , Sichuan 
      University , Chengdu , China.
FAU - Liu, Fang
AU  - Liu F
AD  - a Division of Nephrology , West China Hospital of Sichuan University , Chengdu , 
      China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Nephropathies/etiology/*pathology
MH  - Diabetic Retinopathy/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney Failure, Chronic/*epidemiology
MH  - Kidney Function Tests
MH  - Kidney Glomerulus/pathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC6014304
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - diabetic retinopathy
OT  - renal outcomes
OT  - renal pathology
OT  - risk factors
EDAT- 2018/04/11 06:00
MHDA- 2018/09/19 06:00
PMCR- 2018/04/10
CRDT- 2018/04/11 06:00
PHST- 2018/04/11 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/04/10 00:00 [pmc-release]
AID - 1456453 [pii]
AID - 10.1080/0886022X.2018.1456453 [doi]
PST - ppublish
SO  - Ren Fail. 2018 Nov;40(1):243-251. doi: 10.1080/0886022X.2018.1456453.