PMID- 29635335
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20200218
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 34
IP  - 2
DP  - 2019 Feb 1
TI  - Risk profile, quality of life and care of patients with moderate and advanced 
      CKD: The French CKD-REIN Cohort Study.
PG  - 277-286
LID - 10.1093/ndt/gfy058 [doi]
AB  - BACKGROUND: The French Chronic Kidney Disease-Renal Epidemiology and Information 
      Network (CKD-REIN) cohort study was designed to investigate the determinants of 
      prognosis and care of patients referred to nephrologists with moderate and 
      advanced chronic kidney disease (CKD). We examined their baseline risk profile 
      and experience. METHODS: We collected bioclinical and patient-reported 
      information from 3033 outpatients with CKD and estimated glomerular filtration 
      rates (eGFRs) of 15-60 mL/min/1.73 m2 treated at 40 nationally representative 
      public and private facilities. RESULTS: The patients' median age was 69 
      (60-76) years, 65% were men, their mean eGFR was 33 mL/min/1.73 m2, 43% had 
      diabetes, 24% had a history of acute kidney injury (AKI) and 57% had uncontrolled 
      blood pressure (BP; >140/90 mmHg). Men had worse risk profiles than women and 
      were more likely to be past or current smokers (73% versus 34%) and have 
      cardiovascular disease (59% versus 42%), albuminuria >30 mg/mmol (or proteinuria 
      > 50) (40% versus 30%) (all P < 0.001) and a higher median risk of end-stage 
      renal disease within 5 years, predicted by the kidney failure risk equation 12% 
      [interquartile range (IQR) 3-37%] versus 9% [3-31%], P = 0.008. During the 
      previous year, 60% of patients reported one-to-two nephrologist visits and four 
      or more general practitioner visits; only 25% saw a dietician and 75% were 
      prescribed five or more medications daily. Physical and mental quality of life 
      (QoL) were poor, with scores <50/100. CONCLUSIONS: The CKD-REIN study highlights 
      high-risk profiles of cohort members and identifies several priorities, including 
      improving BP control and dietary counselling and increasing doctors' awareness of 
      AKI, polypharmacy and QoL. TRIAL REGISTRATION: ClinicalTrials.gov identifier: 
      NCT03381950.
FAU - Stengel, Benedicte
AU  - Stengel B
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
FAU - Metzger, Marie
AU  - Metzger M
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
FAU - Combe, Christian
AU  - Combe C
AD  - Service de Nephrologie-Transplantation-Dialyse-Apherese, Centre Hospitalier 
      Universitaire de Bordeaux, Bordeaux, France.
AD  - INSERM, U1026, Universite Bordeaux Segalen, Bordeaux, France.
FAU - Jacquelinet, Christian
AU  - Jacquelinet C
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
AD  - Agence de la Biomedecine, Saint-Denis, France.
FAU - Briancon, Serge
AU  - Briancon S
AD  - Department of Clinical Epidemiology, University Hospital of Nancy, INSERM CIC-EC 
      1433, Nancy, France.
AD  - EA4360 Apemac, Universite de Lorraine, Universite Paris-Descartes, Nancy, France.
FAU - Ayav, Carole
AU  - Ayav C
AD  - Department of Clinical Epidemiology, University Hospital of Nancy, INSERM CIC-EC 
      1433, Nancy, France.
FAU - Fouque, Denis
AU  - Fouque D
AD  - Department of Nephrology, Centre Hospitalier Lyon-Sud, Universite de Lyon, UCBL, 
      Carmen, Pierre-Benite, France.
FAU - Laville, Maurice
AU  - Laville M
AD  - Department of Nephrology, Centre Hospitalier Lyon-Sud, Universite de Lyon, UCBL, 
      Carmen, Pierre-Benite, France.
FAU - Frimat, Luc
AU  - Frimat L
AD  - EA4360 Apemac, Universite de Lorraine, Universite Paris-Descartes, Nancy, France.
AD  - Department of Nephrology, CHU de Nancy, Vandoeuvre-les-Nancy, France.
FAU - Pascal, Christophe
AU  - Pascal C
AD  - Institute for Education and Research in Health Care and Social Service, Jean 
      Moulin Lyon 3 university, Lyon, France.
FAU - Herpe, Yves-Edouard
AU  - Herpe YE
AD  - Biobanque de Picardie, Amiens, France.
AD  - Department of Clinical Pharmacology, Centre Hospitalier Universitaire, Amiens, 
      France.
FAU - Morel, Pascal
AU  - Morel P
AD  - Etablissement Francais du Sang, Bourgogne Franche Comte, Besancon, France.
FAU - Deleuze, Jean-Francois
AU  - Deleuze JF
AD  - Centre National de Recherche en Genomique Humaine (CNRGH), Institut de Biologie 
      Francois-Jacob, CEA, Evry, France.
FAU - Schanstra, Joost P
AU  - Schanstra JP
AD  - INSERM U1048, Institute of Cardiovascular and Metabolic Disease, Toulouse, 
      France.
AD  - Universite Toulouse III Paul-Sabatier, Toulouse, France.
FAU - Lange, Celine
AU  - Lange C
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
AD  - Agence de la Biomedecine, Saint-Denis, France.
FAU - Legrand, Karine
AU  - Legrand K
AD  - Department of Clinical Epidemiology, University Hospital of Nancy, INSERM CIC-EC 
      1433, Nancy, France.
AD  - EA4360 Apemac, Universite de Lorraine, Universite Paris-Descartes, Nancy, France.
FAU - Speyer, Elodie
AU  - Speyer E
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
FAU - Liabeuf, Sophie
AU  - Liabeuf S
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
AD  - Department of Clinical Pharmacology, Centre Hospitalier Universitaire, Amiens, 
      France.
FAU - Robinson, Bruce M
AU  - Robinson BM
AD  - Arbor Research Collaborative for Health, Ann Arbor, MI, USA.
FAU - Massy, Ziad A
AU  - Massy ZA
AD  - Centre for Research in Epidemiology and Population Health (CESP), UMRS 1018, 
      Universite Paris-Sud, UVSQ, Universite Paris-Saclay, Villejuif, France.
AD  - Department of Nephrology, CHU Ambroise Pare, Boulogne, France.
LA  - eng
SI  - ClinicalTrials.gov/NCT03381950
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - Acute Kidney Injury
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/complications
MH  - Blood Pressure
MH  - Cardiovascular Diseases/complications/epidemiology
MH  - Diabetes Mellitus/epidemiology
MH  - Female
MH  - France
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney Failure, Chronic/complications/psychology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Prognosis
MH  - Prospective Studies
MH  - Proteinuria/complications
MH  - *Quality of Life
MH  - Risk Factors
EDAT- 2018/04/11 06:00
MHDA- 2020/02/19 06:00
CRDT- 2018/04/11 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2018/02/01 00:00 [accepted]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2018/04/11 06:00 [entrez]
AID - 4963503 [pii]
AID - 10.1093/ndt/gfy058 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2019 Feb 1;34(2):277-286. doi: 10.1093/ndt/gfy058.