PMID- 29636665
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 12
DP  - 2018
TI  - Regulation of Brain-Derived Neurotrophic Factor and Growth Factor Signaling 
      Pathways by Tyrosine Phosphatase Shp2 in the Retina: A Brief Review.
PG  - 85
LID - 10.3389/fncel.2018.00085 [doi]
LID - 85
AB  - SH2 domain-containing tyrosine phosphatase-2 (PTPN11 or Shp2) is a ubiquitously 
      expressed protein that plays a key regulatory role in cell proliferation, 
      differentiation and growth factor (GF) signaling. This enzyme is well expressed 
      in various retinal neurons and has emerged as an important player in regulating 
      survival signaling networks in the neuronal tissues. The non-receptor phosphatase 
      can translocate to lipid rafts in the membrane and has been implicated to 
      regulate several signaling modules including PI3K/Akt, JAK-STAT and Mitogen 
      Activated Protein Kinase (MAPK) pathways in a wide range of biochemical processes 
      in healthy and diseased states. This review focuses on the roles of Shp2 
      phosphatase in regulating brain-derived neurotrophic factor (BDNF) neurotrophin 
      signaling pathways and discusses its cross-talk with various GF and downstream 
      signaling pathways in the retina.
FAU - Abbasi, Mojdeh
AU  - Abbasi M
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
FAU - Gupta, Vivek
AU  - Gupta V
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
FAU - Chitranshi, Nitin
AU  - Chitranshi N
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
FAU - You, Yuyi
AU  - You Y
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
AD  - Save Sight Institute, University of Sydney, Sydney, NSW, Australia.
FAU - Dheer, Yogita
AU  - Dheer Y
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
FAU - Mirzaei, Mehdi
AU  - Mirzaei M
AD  - Australian Proteome Analysis Facility, Macquarie University, Sydney, NSW, 
      Australia.
AD  - Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
FAU - Graham, Stuart L
AU  - Graham SL
AD  - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, 
      Australia.
AD  - Save Sight Institute, University of Sydney, Sydney, NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180327
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC5880906
OTO - NOTNLM
OT  - BDNF neurotrophin
OT  - Shp2 phosphatase
OT  - TrkB receptor
OT  - growth factors
OT  - retina
EDAT- 2018/04/11 06:00
MHDA- 2018/04/11 06:01
PMCR- 2018/01/01
CRDT- 2018/04/12 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/03/09 00:00 [accepted]
PHST- 2018/04/12 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/04/11 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2018.00085 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2018 Mar 27;12:85. doi: 10.3389/fncel.2018.00085. 
      eCollection 2018.