PMID- 29636708
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 9
DP  - 2018
TI  - Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and 
      Histone Modifications of Brain-Derived Neurotrophic Factor.
PG  - 102
LID - 10.3389/fpsyt.2018.00102 [doi]
LID - 102
AB  - Sensitive and stable biomarkers that facilitate depression detection and monitor 
      the antidepressant efficiency are currently unavailable. Thus, the objective is 
      to investigate the potential of DNA methylation and histone modifications of 
      brain-derived neurotrophic factor (BDNF) in monitoring severity and 
      antidepressive effects of acupuncture. The depression rat model was imitated by 
      social isolation and chronic unpredicted mild stress (CUMS). The expression of 
      serum BDNF was detected by enzyme-linked immunosorbent assay (ELISA), the 
      hippocampal BDNF, acetylation levels in histone H3 lysine 9 (acH3K9), and HDAC2 
      by Western blot, the hippocampal mRNA of BDNF by RT-polymerase chain reaction 
      (PCR). The DNA methylation patterns of the promoter I of BDNF was detected by 
      MS-PCR. We investigated that the expression of BDNF in serum and hippocampus were 
      significantly downregulated compared with controls. The same trend was found in 
      mRNA of BDNF. Notably, acupuncture reversed the downregulation of BDNF in serum 
      and hippocampus and mRNA of BDNF compared with model group. Acupuncture reversed 
      the CUMS-induced downregulation of hippocampal acH3K9. On the contrary, the 
      CUMS-induced upregulation of hippocampal HDAC2 in model group was significantly 
      reversed by acupuncture. Collectively, the antidepressant effect of acupuncture 
      might be mediated by regulating the DNA methylation and histone modifications of 
      BDNF, which may represent novel biomaker for detection of depression and 
      monitoring severity and antidepressive effects.
FAU - Jiang, Huili
AU  - Jiang H
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Zhang, Xuhui
AU  - Zhang X
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Lu, Jun
AU  - Lu J
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Meng, Hong
AU  - Meng H
AD  - School of Science, Beijing Technology and Business University, Beijing, China.
FAU - Sun, Yang
AU  - Sun Y
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Yang, Xinjing
AU  - Yang X
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Zhao, Bingcong
AU  - Zhao B
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Bao, Tuya
AU  - Bao T
AD  - School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Research Center of Mental and Neurological Disorders, School of 
      Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20180327
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5880910
OTO - NOTNLM
OT  - DNA methylation
OT  - acupuncture
OT  - brain-derived neurotrophic factor
OT  - depression
OT  - histone modifications
EDAT- 2018/04/11 06:00
MHDA- 2018/04/11 06:01
PMCR- 2018/03/27
CRDT- 2018/04/12 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2018/03/14 00:00 [accepted]
PHST- 2018/04/12 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/04/11 06:01 [medline]
PHST- 2018/03/27 00:00 [pmc-release]
AID - 10.3389/fpsyt.2018.00102 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 
      2018.