PMID- 29637008
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2156-6976 (Print)
IS  - 2156-6976 (Electronic)
IS  - 2156-6976 (Linking)
VI  - 8
IP  - 3
DP  - 2018
TI  - Overexpression of golgi membrane protein 1 promotes non-small-cell carcinoma 
      aggressiveness by regulating the matrix metallopeptidase 13.
PG  - 551-565
AB  - Non-small-cell carcinoma (NSCLC) is one of the most lethal malignancies of lung 
      cancers and its prognosis remains dismal due to the paucity of effective 
      therapeutic targets. Recent reports show that Golgi membrane protein 1 (GOLM1) is 
      highly expressed in a variety of tumor cells, functions as a negative regulator 
      of T cells and then promotes tumor progression. However, its expression and role 
      in NSCLC remain unclear. Herein, we showed that GOLM1 was markedly up-regulated 
      in NSCLC cell lines and clinical tissues. Clinically, NSCLC patients with high 
      expression of GOLM1 had shorter overall survival (OS) and high GOLM1 expression 
      in tumor samples was significantly related to malignant phenotype, such as lymph 
      node metastasis and high tumor stage. Ectopic expression of GOLM1 in NSCLC cells 
      induced epithelial-to-mesenchymal transition (EMT) and promoted proliferation, 
      migration, and invasion of NSCLC cells in vitro. Furthermore, GOLM1 
      overexpressing significantly promoted the tumorigenicity of NSCLC cells in vivo 
      whereas silencing endogenous GOLM1 caused an opposite outcome. Moreover, we 
      demonstrated that GOLM1 enhanced NSCLC aggressiveness by activating matrix 
      metalloproteinase-13 (MMP13) signaling. Together, our results provided new 
      evidence that GOLM1 overexpression promoted the progression of NSCLC and might 
      represent a novel therapeutic target for its treatment.
FAU - Aruna
AU  - Aruna
AD  - The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016, 
      China.
AD  - Inner Mongolia People's HospitalHohhot 010017, China.
FAU - Li, Li Mei
AU  - Li LM
AD  - The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016, 
      China.
AD  - Inner Mongolia People's HospitalHohhot 010017, China.
LA  - eng
PT  - Journal Article
DEP - 20180301
PL  - United States
TA  - Am J Cancer Res
JT  - American journal of cancer research
JID - 101549944
PMC - PMC5883103
OTO - NOTNLM
OT  - GOLM1
OT  - MMP13
OT  - NSCLC
OT  - metastasis
COIS- None.
EDAT- 2018/04/11 06:00
MHDA- 2018/04/11 06:01
PMCR- 2018/03/01
CRDT- 2018/04/12 06:00
PHST- 2018/01/24 00:00 [received]
PHST- 2018/02/04 00:00 [accepted]
PHST- 2018/04/12 06:00 [entrez]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/04/11 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
PST - epublish
SO  - Am J Cancer Res. 2018 Mar 1;8(3):551-565. eCollection 2018.