PMID- 29637559
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20221207
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 142
IP  - 1
DP  - 2018 Jul
TI  - Low-grade squamous intraepithelial lesions among women with HIV.
PG  - 78-83
LID - 10.1002/ijgo.12505 [doi]
AB  - OBJECTIVES: To assess whether women with HIV who had low-grade squamous 
      intraepithelial lesions (LSIL) on cytology had cervical disease. METHODS: The 
      present retrospective cross-sectional study included data from women with LSIL 
      who attended a tertiary hospital in South Africa between April 1, 2003, and 
      December 31, 2013. Patient information was extracted from a colposcopy database. 
      RESULTS: The study included 652 patients. The median age was 36 years 
      (interquartile range [IQR] 31-42 years; range 18-66 years) and the median parity 
      was three (IQR 2-5; range 0-10). In all, 266 (40.8%) women had a histology result 
      of HPV or cervical intraepithelial neoplasia 1 (CIN1); 386 (59.2%) had a 
      histology result of CIN2 or higher. The median cluster of differentiation 4 (CD4) 
      count was 275.00 cells/mm(3) (IQR 173.50-434.00 cells/mm(3) ; range 2-1211 
      cells/mm(3) ). A total of 312 (47.9%) women were using antiretroviral therapy. 
      Use of antiretroviral therapy (unadjusted odds ratio 0.57; P=0.001) and a CD4 
      count of at least 200 cells/mm(3) (unadjusted odds ratio 0.81; P=0.002) were 
      associated with a histology result of HPV or CIN1. CONCLUSION: Most of the women 
      with a cytology report of LSIL had CIN2 or higher, suggesting that the practice 
      of referral for colposcopy should continue.
CI  - (c) 2018 International Federation of Gynecology and Obstetrics.
FAU - Manamela, Portia K
AU  - Manamela PK
AD  - Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Academic 
      Hospital, Johannesburg, South Africa.
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
FAU - Kgomo, Koena A
AU  - Kgomo KA
AD  - Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Academic 
      Hospital, Johannesburg, South Africa.
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
FAU - van Gelderen, Cyril J
AU  - van Gelderen CJ
AD  - Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Academic 
      Hospital, Johannesburg, South Africa.
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
FAU - Lekha, Anushka R
AU  - Lekha AR
AD  - Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Academic 
      Hospital, Johannesburg, South Africa.
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
FAU - Michelow, Pamela
AU  - Michelow P
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
AD  - Department of Anatomical Pathology, Faculty of Health Science, National Health 
      Laboratory Service, Johannesburg, South Africa.
FAU - van den Berg, Eunice J
AU  - van den Berg EJ
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
AD  - Department of Anatomical Pathology, Faculty of Health Science, National Health 
      Laboratory Service, Johannesburg, South Africa.
FAU - Adam, Yasmin
AU  - Adam Y
AD  - Department of Obstetrics and Gynaecology, Chris Hani Baragwanath Academic 
      Hospital, Johannesburg, South Africa.
AD  - School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South 
      Africa.
LA  - eng
PT  - Journal Article
DEP - 20180424
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Colposcopy
MH  - Cross-Sectional Studies
MH  - Cytodiagnosis
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Middle Aged
MH  - Papillomavirus Infections/epidemiology
MH  - Pregnancy
MH  - Referral and Consultation
MH  - Retrospective Studies
MH  - South Africa
MH  - Squamous Intraepithelial Lesions of the Cervix/*epidemiology/pathology
MH  - Vaginal Smears
MH  - Young Adult
MH  - Uterine Cervical Dysplasia/*epidemiology/pathology
OTO - NOTNLM
OT  - Cervical cancer precursor lesions
OT  - Cervical intraepithelial neoplasia
OT  - HIV
OT  - LSIL
OT  - Papanicolaou
OT  - South Africa
EDAT- 2018/04/11 06:00
MHDA- 2018/09/18 06:00
CRDT- 2018/04/12 06:00
PHST- 2017/11/15 00:00 [received]
PHST- 2018/01/23 00:00 [revised]
PHST- 2018/04/05 00:00 [accepted]
PHST- 2018/04/11 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/04/12 06:00 [entrez]
AID - 10.1002/ijgo.12505 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2018 Jul;142(1):78-83. doi: 10.1002/ijgo.12505. Epub 2018 
      Apr 24.