PMID- 29637820
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20190304
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Print)
IS  - 0963-6897 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal 
      Stem Cell Infusion for Children With Cerebral Palsy.
PG  - 325-334
LID - 10.1177/0963689717729379 [doi]
AB  - Cerebral palsy (CP) is a common disability which results in permanent chronic 
      motor disability appearing in early childhood. Recently human umbilical cord 
      blood mesenchymal stem cell (hUCB-MSC) infusion has emerged as a promising 
      therapeutic strategy for CP, and the treatment efficacy remains to be confirmed 
      by clinical trials. All 54 patients received basic rehabilitation as a background 
      treatment. The infusion group comprising 27 patients received 4 infusions of 
      hUCB-MSCs (intravenous infusions at a fixed dose of 5 x 10(7)) and basic 
      rehabilitation treatment, whereas 27 patients in the control group received 0.9% 
      normal saline and basic rehabilitation treatment. Several indices were tested 
      from baseline up to 24 months posttreatment regarding efficacy and safety 
      evaluations, including the gross motor function measurement 88 (GMFM-88) scores, 
      the comprehensive function assessment (CFA), lab tests, electroencephalogram 
      (EEG), routine magnetic resonance imaging (MRI), and adverse events. The changes 
      in the total proportion of GMFM-88 and total scores of CFA in the hUCB-MSC 
      infusion group were significantly higher than that in control group at 3, 6, 12, 
      24 months posttreatment. Less diffuse slow waves were noticed after hUCB-MSC 
      infusion in patients with slowing of EEG background rhythms at baseline. Based on 
      the routine MRI exams, improvements in cerebral structures were rare after 
      treatment. Serious adverse events were not observed during the whole study 
      period. The results of the study indicated that hUCB-MSC infusion with basic 
      rehabilitation was safe and effective in improving gross motor and comprehensive 
      functions in children with CP.
FAU - Huang, Li
AU  - Huang L
AD  - 1 Institute of Neurobiology and Department of Human Anatomy & Histoembriology, 
      School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shanxi, 
      People Republic of China.
AD  - 2 Taihe Hospital Affiliated to Hubei Medical College, Shiyan, Hubei, People 
      Republic of China.
FAU - Zhang, Che
AU  - Zhang C
AD  - 2 Taihe Hospital Affiliated to Hubei Medical College, Shiyan, Hubei, People 
      Republic of China.
AD  - 3 Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shanxi, People Republic of China.
FAU - Gu, Jiaowei
AU  - Gu J
AD  - 2 Taihe Hospital Affiliated to Hubei Medical College, Shiyan, Hubei, People 
      Republic of China.
FAU - Wu, Wei
AU  - Wu W
AD  - 2 Taihe Hospital Affiliated to Hubei Medical College, Shiyan, Hubei, People 
      Republic of China.
FAU - Shen, Zhujun
AU  - Shen Z
AD  - 2 Taihe Hospital Affiliated to Hubei Medical College, Shiyan, Hubei, People 
      Republic of China.
FAU - Zhou, Xihui
AU  - Zhou X
AD  - 3 Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shanxi, People Republic of China.
FAU - Lu, Haixia
AU  - Lu H
AD  - 1 Institute of Neurobiology and Department of Human Anatomy & Histoembriology, 
      School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shanxi, 
      People Republic of China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
SB  - IM
MH  - Cerebral Palsy/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Electroencephalography
MH  - Female
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cells/*cytology/*physiology
PMC - PMC5898688
OTO - NOTNLM
OT  - cerebral palsy
OT  - clinical trial
OT  - human umbilical cord blood mesenchymal stem cells
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/04/12 06:00
MHDA- 2019/03/05 06:00
PMCR- 2018/02/01
CRDT- 2018/04/12 06:00
PHST- 2018/04/12 06:00 [entrez]
PHST- 2018/04/12 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1177_0963689717729379 [pii]
AID - 10.1177/0963689717729379 [doi]
PST - ppublish
SO  - Cell Transplant. 2018 Feb;27(2):325-334. doi: 10.1177/0963689717729379.