PMID- 29641751
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20220318
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Print)
IS  - 1678-7757 (Linking)
VI  - 26
DP  - 2018 Apr 5
TI  - Association between TNFalpha - 308 G/A polymorphism and oral lichen planus (OLP): a 
      meta-analysis.
PG  - e20170184
LID - S1678-77572018000100434 [pii]
LID - 10.1590/1678-7757-2017-0184 [doi]
LID - e20170184
AB  - OBJECTIVES: To determine whether Tumor Necrosis Factor alpha (TNFalpha) -308 G/A 
      polymorphism is associated with oral lichen planus (OLP). MATERIAL AND METHODS: A 
      systematic electronic search of the literature was conducted to identify all 
      published studies on the association between TNFalpha -308 G/A polymorphism and OLP. 
      All case-control studies evaluating the TNFalpha -308 G/A polymorphisms in OLP were 
      selected. A meta-analysis of the studies that fulfilled the inclusion criteria 
      was performed. Odds ratios (OR) with 95% confidence intervals (CI) were also 
      calculated. RESULTS: Seven studies comprising 450 OLP cases and 867 controls were 
      included in the meta-analysis. In the pooled analysis, TNFalpha -308 G/A polymorphism 
      was associated with OLP with random effects and OR of 2.33 (95%CI=1.07-5.11; 
      p=0.03), assuming a dominant mode of inheritance (AA+GA vs. GG). In the subgroup 
      analysis by ethnicity, TNFalpha -308 G/A was associated with a significantly 
      increased odds ratio of OLP in mixed ethnicity (OR=5.22; 95%CI=1.93-14.15; 
      p=0.001), but not in Asians (OR=1.57; 95%CI=0.54-4.54; p=0.41) or Caucasians 
      (OR=1.45; 95%CI=0.19-11.22; p=0.72). For subgroup analysis based on HCV 
      (hepatitis C virus) infection status, significant increased risk of OLP was found 
      among patients with mixed HCV infection status (OR=3.77; 95%CI=1.07-13.2; 
      p=0.038), but not in patients without HCV infection (OR=2.09; 95%CI=0.63-6.91; 
      p=0.22) and patients with HCV infection (OR=0.48; 95%CI=0.13-1.69; p=0.25). 
      CONCLUSION: Our results suggest that -308 G/A polymorphism in TNFalpha is a potential 
      genetic marker for OLP.
FAU - Zhou, Yuqiao
AU  - Zhou Y
AD  - Sichuan University, West China College of Stomatology, State Key Laboratory of 
      Oral Diseases, Chengdu, China.
AD  - University of Pittsburgh, School of Dental Medicine, Department of Oral Biology, 
      Pittsburgh, PA, U.S.A.
FAU - Vieira, Alexandre Rezende
AU  - Vieira AR
AD  - University of Pittsburgh, School of Dental Medicine, Department of Oral Biology, 
      Pittsburgh, PA, U.S.A.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180405
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
RN  - 0 (Genetic Markers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Genetic Association Studies
MH  - Genetic Markers
MH  - Humans
MH  - Lichen Planus, Oral/*genetics
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC5912397
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2018/04/12 06:00
MHDA- 2018/05/01 06:00
PMCR- 2018/03/26
CRDT- 2018/04/12 06:00
PHST- 2017/04/26 00:00 [received]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2018/04/12 06:00 [entrez]
PHST- 2018/04/12 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2018/03/26 00:00 [pmc-release]
AID - S1678-77572018000100434 [pii]
AID - 10.1590/1678-7757-2017-0184 [doi]
PST - epublish
SO  - J Appl Oral Sci. 2018 Apr 5;26:e20170184. doi: 10.1590/1678-7757-2017-0184.