PMID- 29642997
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20220408
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 264
DP  - 2018 Aug 1
TI  - Gender differences in symptom presentation of ST-elevation myocardial infarction 
      - An observational multicenter survey study.
PG  - 7-11
LID - S0167-5273(17)36650-0 [pii]
LID - 10.1016/j.ijcard.2018.03.084 [doi]
AB  - BACKGROUND: Symptom presentation has been sparsely studied from a gender 
      perspective restricting the inclusion to ST elevation myocardial infarction 
      (STEMI) patients. Correct symptom recognition is vital in order to promptly seek 
      care in STEMI where fast reperfusion therapy is of utmost importance. Female 
      gender has been found associated with atypical presentation in studies on mixed 
      MI populations but it is unclear whether this is valid also in STEMI. OBJECTIVES: 
      We assessed whether there are gender differences in symptoms and interpretation 
      of these in STEMI, and if this is attributable to sociodemographic and clinical 
      factors. METHODS: SymTime was a multicenter observational study including a 
      validated questionnaire and data from medical records. Eligible STEMI patients 
      (n = 532) were enrolled within 24 h after admittance at five Swedish hospitals. 
      RESULTS: Women were older, more often single and had lower educational level. 
      Chest pain was less prevalent in women (74 vs 93%, p < 0.001), whereas shoulder 
      (33 vs 15%, p < 0.001), throat/neck (34 vs 18%, p < 0.001), back pain (29 versus 
      12%, p < 0.001) and nausea (49 vs 29%, p < 0.001) were more prevalent. Women less 
      often interpreted their symptoms as of cardiac origin (60 vs 69%, p = 0.04). 
      Female gender was the strongest independent predictor of non-chest pain 
      presentation, odds ratio 5.29, 95% confidence interval 2.85-9.80. CONCLUSIONS: A 
      striking gender difference in STEMI symptoms was found. As women significantly 
      misinterpreted their symptoms more often, it is vital when informing about MI to 
      the society or to high risk individuals, to highlight also other symptoms than 
      just chest pain.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sederholm Lawesson, Sofia
AU  - Sederholm Lawesson S
AD  - Department of Cardiology, Department of Medical and Health Sciences, Linkoping 
      University, Linkoping, Sweden. Electronic address: Sofia.Lawesson@liu.se.
FAU - Isaksson, Rose-Marie
AU  - Isaksson RM
AD  - Department of Research, Norrbotten County Council, Lulea, Sweden; Division of 
      Nursing Sciences, Department of Medicine and Health Sciences, Linkoping 
      University, Linkoping, Sweden. Electronic address: 
      rose-marie.isaksson@norrbotten.se.
FAU - Thylen, Ingela
AU  - Thylen I
AD  - Department of Cardiology, Department of Medical and Health Sciences, Linkoping 
      University, Linkoping, Sweden. Electronic address: 
      ingela.thylen@regionostergotland.se.
FAU - Ericsson, Maria
AU  - Ericsson M
AD  - Department of Cardiology, Department of Medical and Health Sciences, Linkoping 
      University, Linkoping, Sweden. Electronic address: 
      maria.eriksson@regionostergotland.se.
FAU - Angerud, Karin
AU  - Angerud K
AD  - Cardiology, Heart Centre, Department of Nursing, Umea University, Umea, Sweden. 
      Electronic address: karin.hellstrom.angerud@umu.se.
FAU - Swahn, Eva
AU  - Swahn E
AD  - Department of Cardiology, Department of Medical and Health Sciences, Linkoping 
      University, Linkoping, Sweden. Electronic address: eva.swahn@liu.se.
CN  - SymTime Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20180324
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Demography
MH  - Diagnosis, Differential
MH  - Electrocardiography/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pain/classification/diagnosis
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - *ST Elevation Myocardial Infarction/diagnosis/epidemiology/physiopathology
MH  - *Sex Factors
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Sweden/epidemiology
MH  - *Symptom Assessment/methods/statistics & numerical data
MH  - Time-to-Treatment
OTO - NOTNLM
OT  - Chest pain
OT  - Clinical presentation
OT  - Gender
OT  - ST-elevation myocardial infarction
OT  - Symptoms
EDAT- 2018/04/13 06:00
MHDA- 2019/01/10 06:00
CRDT- 2018/04/13 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/03/14 00:00 [revised]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2018/04/13 06:00 [entrez]
AID - S0167-5273(17)36650-0 [pii]
AID - 10.1016/j.ijcard.2018.03.084 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 Aug 1;264:7-11. doi: 10.1016/j.ijcard.2018.03.084. Epub 2018 
      Mar 24.