PMID- 29643431
OWN - NLM
STAT- MEDLINE
DCOM- 20191025
LR  - 20220410
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Apr 11
TI  - An estradiol-independent BDNF-NPY cascade is involved in the antidepressant 
      effect of mechanical acupuncture instruments in ovariectomized rats.
PG  - 5849
LID - 10.1038/s41598-018-23824-2 [doi]
LID - 5849
AB  - Menopause-related depression devastates women's quality of life after middle age. 
      Previous research has shown that estrogen hormone therapy has serious adverse 
      effects; thus, complementary and integrative therapies have been considered 
      clinically. The present study investigates whether stimulation of an acupoint 
      using a mechanical acupuncture instrument (MAI) can mitigate depression-like 
      behavior caused by estrogen deficiency in ovariectomized (OVX) rats. The animals 
      were divided into Sham OVX, OVX, OVX + Sameumgyo (SP6) and OVX + NonAcu 
      (non-acupuncture point) groups. MAI stimulation significantly increased the total 
      distance traveled in the open-field test and the number of open-arm entries in 
      the elevated plus maze and decreased the duration of immobility in the forced 
      swim test. In addition to this decrease in depression-like behavior, 
      brain-derived neurotrophic factor (BDNF) and neuropeptide Y (NPY) release 
      increased in the hippocampus in response to MAI treatment, but estradiol levels 
      did not recover. Furthermore, microinjection of the BDNF receptor antagonist 
      ANA-12 (0.1 pmol/1 mul) into the hippocampus before MAI stimulation significantly 
      suppressed the recovery of NPY levels. Taken together, these findings indicate 
      that MAI stimulation at SP6 facilitates an estradiol-independent BDNF-NPY 
      cascade, which may contribute to its antidepressant effects in OVX rats, an 
      animal model of menopausal disorders.
FAU - Seo, Su Yeon
AU  - Seo SY
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Moon, Ji-Young
AU  - Moon JY
AD  - Animal and Plant Quarantine Agency 177, Hyeoksin 8-ro, Gimcheon-si, 
      Gyeongsangbuk-do, Republic of Korea.
FAU - Kang, Suk-Yun
AU  - Kang SY
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Kwon, O Sang
AU  - Kwon OS
AUID- ORCID: 0000-0001-5686-579X
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Kwon, Sunoh
AU  - Kwon S
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Bang, Se Kyun
AU  - Bang SK
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Kim, Soo Phil
AU  - Kim SP
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Choi, Kwang-Ho
AU  - Choi KH
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea.
FAU - Ryu, Yeonhee
AU  - Ryu Y
AD  - Korea Institute of Oriental Medicine 1672 Yuseongdae-ro, Yuseong-gu, Daejeon, 
      34054, Republic of Korea. yhryu@kiom.re.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180411
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - *Acupuncture Points
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/etiology/metabolism/psychology/*therapy
MH  - Disease Models, Animal
MH  - Estradiol/metabolism
MH  - Female
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Menopause/metabolism/*psychology
MH  - Neuropeptide Y/*metabolism
MH  - Ovariectomy/adverse effects
MH  - Rats
MH  - Treatment Outcome
PMC - PMC5895789
COIS- The authors declare no competing interests.
EDAT- 2018/04/13 06:00
MHDA- 2019/10/28 06:00
PMCR- 2018/04/11
CRDT- 2018/04/13 06:00
PHST- 2017/07/13 00:00 [received]
PHST- 2018/03/19 00:00 [accepted]
PHST- 2018/04/13 06:00 [entrez]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/10/28 06:00 [medline]
PHST- 2018/04/11 00:00 [pmc-release]
AID - 10.1038/s41598-018-23824-2 [pii]
AID - 23824 [pii]
AID - 10.1038/s41598-018-23824-2 [doi]
PST - epublish
SO  - Sci Rep. 2018 Apr 11;8(1):5849. doi: 10.1038/s41598-018-23824-2.