PMID- 29643835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 9
DP  - 2018
TI  - Identification of Neuroendocrine Stress Response-Related Circulating MicroRNAs as 
      Biomarkers for Type 2 Diabetes Mellitus and Insulin Resistance.
PG  - 132
LID - 10.3389/fendo.2018.00132 [doi]
LID - 132
AB  - BACKGROUND: Chronic stress plays an important role in the development of type 2 
      diabetes mellitus (T2DM) and insulin resistance (IR). MicroRNAs (miRNAs) play key 
      roles in mediating stress responses by regulating the expression of target genes. 
      This study systematically screened and identified the neuroendocrine stress 
      response-related circulating miRNAs which are associated with T2DM and IR. 
      METHODS: Based on the differential plasma expression profiles between individuals 
      with and without T2DM, stress-related miRNAs were selected from those differently 
      expressed miRNAs whose targets are involved in known neuroendocrine pathway of 
      stress response. Candidate miRNAs were further validated by quantitative 
      real-time polymerase chain reaction in a large sample, including 112 T2DM 
      patients, 72 individuals with impaired fasting glucose (IFG), and 94 healthy 
      controls. The association between miRNA expression and potential risk of T2DM and 
      IFG was assessed by multivariate logistic regression models. The miRNA predictors 
      of IR were identified by stepwise multiple regression analysis. The diagnostic 
      performance for T2DM was evaluated by area under the curve (AUC) of receiver 
      operating characteristic (ROC). RESULTS: let-7b, let-7i, miR-142, miR-144, 
      miR-155, and miR-29a were selected as candidate miRNAs for validation. Increased 
      expression of let-7b, miR-144, and miR-29a and decreased expression of miR-142 
      were significant independent predictors of T2DM, IFG, and IR (P < 0.0125). These 
      miRNAs significantly correlated with stress hormone levels (P < 0.0125). A 
      three-miRNA panel, including let-7b, miR-142, and miR-144 had a high accuracy for 
      diagnosing T2DM (AUC = 0.871, 95% CI: 0.822-0.919). CONCLUSION: let-7b, miR-142, 
      miR-144, and miR-29a in plasma may be important markers of neuroendocrine stress 
      response and may play a role in the pathogenesis of T2DM and IR.
FAU - Liang, Ying-Zhi
AU  - Liang YZ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Capital 
      Medical University, Beijing, China.
AD  - Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
FAU - Dong, Jing
AU  - Dong J
AD  - Health Medical Examination Center, Xuanwu Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Capital 
      Medical University, Beijing, China.
AD  - Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
FAU - Wang, Shuo
AU  - Wang S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Capital 
      Medical University, Beijing, China.
AD  - Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
FAU - He, Yan
AU  - He Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Capital 
      Medical University, Beijing, China.
AD  - Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
FAU - Yan, Yu-Xiang
AU  - Yan YX
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Capital 
      Medical University, Beijing, China.
AD  - Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20180328
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC5882838
OTO - NOTNLM
OT  - biomarker
OT  - insulin resistance
OT  - microRNA
OT  - neuroendocrine
OT  - stress
OT  - type 2 diabetes mellitus
EDAT- 2018/04/13 06:00
MHDA- 2018/04/13 06:01
PMCR- 2018/01/01
CRDT- 2018/04/13 06:00
PHST- 2017/10/18 00:00 [received]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/04/13 06:00 [entrez]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2018/04/13 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2018.00132 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2018 Mar 28;9:132. doi: 10.3389/fendo.2018.00132. 
      eCollection 2018.