PMID- 29644619
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 9
IP  - 3
DP  - 2018 Jun
TI  - Early (</= 30 Days), Late (31-360 Days) and Very Late (> 360 Days) Stent Thrombosis 
      in Patients with Insulin-Treated versus Non-Insulin-Treated Type 2 Diabetes 
      Mellitus: A Meta-Analysis.
PG  - 1113-1124
LID - 10.1007/s13300-018-0425-1 [doi]
AB  - INTRODUCTION: At this time in 2018, with type 2 diabetes mellitus (T2DM) and 
      coronary artery disease (CAD) still on the rise, the post-percutaneous coronary 
      interventional (PCI) outcomes observed in patients with diabetes mellitus who are 
      on insulin therapy (ITDM) and those who do not require insulin (NITDM) are still 
      controversial and require further investigation. Considering this idea to be of 
      particular interest to the readers, as well as being an important issue in 
      interventional cardiology, we aimed to systematically assess early (</= 30 days), 
      late (31-360 days) and very late (> 360 days) stent thrombosis in patients with 
      ITDM and NITDM following drug-eluting stent (DES) implantation. METHODS: 
      Well-known online databases (the Cochrane, EMBASE and MEDLINE databases and 
      http://www.ClinicalTrials.gov ) were searched for relevant English publications 
      based on ITDM and NITDM and stent thrombosis following PCI using specific terms. 
      Early stent thrombosis, late stent thrombosis and very late stent thrombosis were 
      the clinical outcomes. The main analysis was carried out using the latest version 
      of the RevMan software (version 5.3) whereby odds ratios (OR), and 95% confidence 
      intervals (CI) were generated. RESULTS: A total of 8524 participants with T2DM 
      (2273 participants were on insulin therapy and 6251 participants were not) were 
      included. Results of this analysis showed early stent thrombosis to be 
      significantly higher in patients with ITDM (OR 1.81, 95% CI 1.04-3.15; P = 0.04), 
      whereas late and very late stent thromboses were not significantly different 
      following PCI with DES in diabetic patients with versus without insulin therapy 
      (OR 1.44, 95% CI 0.73-2.84, P = 0.30 and OR 0.80, 95% CI 0.33-1.92, P = 0.62, 
      respectively). Late stent thromboses associated exclusively with 
      everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) were not 
      significantly different in patients with ITDM and NITDM. CONCLUSION: Following 
      PCI with DES, early stent thrombosis was significantly higher in patients with 
      ITDM. However, late and very late stent thromboses were not significantly 
      different in patients with type 2 diabetes mellitus who were treated with or 
      without insulin. Comparison with individual DES was not sufficiently powerful to 
      reach a conclusion.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Cardiology, Guilin People's Hospital, No. 12, Wenming Road, Guilin, 
      541002, Guangxi, China.
FAU - Wu, Yubin
AU  - Wu Y
AD  - Department of Cardiology, Guilin People's Hospital, No. 12, Wenming Road, Guilin, 
      541002, Guangxi, China. wyb201819@163.com.
FAU - Hu, Yubao
AU  - Hu Y
AD  - Department of Cardiology, Guilin People's Hospital, No. 12, Wenming Road, Guilin, 
      541002, Guangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20180411
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC5984928
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Drug-eluting stents
OT  - Early stent thrombosis
OT  - Insulin-treated type 2 diabetes mellitus
OT  - Late stent thrombosis
OT  - Percutaneous coronary intervention
EDAT- 2018/04/13 06:00
MHDA- 2018/04/13 06:01
PMCR- 2018/04/11
CRDT- 2018/04/13 06:00
PHST- 2018/03/23 00:00 [received]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2018/04/13 06:01 [medline]
PHST- 2018/04/13 06:00 [entrez]
PHST- 2018/04/11 00:00 [pmc-release]
AID - 10.1007/s13300-018-0425-1 [pii]
AID - 425 [pii]
AID - 10.1007/s13300-018-0425-1 [doi]
PST - ppublish
SO  - Diabetes Ther. 2018 Jun;9(3):1113-1124. doi: 10.1007/s13300-018-0425-1. Epub 2018 
      Apr 11.