PMID- 29644956
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 119
IP  - 8
DP  - 2018 Apr
TI  - Genetic polymorphisms of key enzymes in folate metabolism affect the efficacy of 
      folate therapy in patients with hyperhomocysteinaemia.
PG  - 887-895
LID - 10.1017/S0007114518000508 [doi]
AB  - The aim of this study is to analyse the efficacy rate of folate for the treatment 
      of hyperhomocysteinaemia (HHcy) and to explore how folate metabolism-related gene 
      polymorphisms change its efficacy. This study also explored the effects of 
      gene-gene and gene-environment interactions on the efficacy of folate. A 
      prospective cohort study enrolling HHcy patients was performed. The subjects were 
      treated with oral folate (5 mg/d) for 90 d. We analysed the efficacy rate of 
      folate for the treatment of HHcy by measuring homocysteine (Hcy) levels after 
      treatment. Unconditioned logistic regression was conducted to analyse the 
      association between SNP and the efficacy of folic acid therapy for HHcy. The 
      efficacy rate of folate therapy for HHcy was 56.41 %. The MTHFR rs1801133 CT 
      genotype, TT genotype and T allele; the MTHFR rs1801131 AC genotype, CC genotype 
      and C allele; the MTRR rs1801394 GA genotype, GG genotype and G allele; and the 
      MTRR rs162036 AG genotype and AG+GG genotypes were associated with the efficacy 
      of folic acid therapy for HHcy (P<0.05). No association was seen between other 
      SNP and the efficacy of folic acid. The optimal model of gene-gene interactions 
      was a two-factor interaction model including rs1801133 and rs1801394. The optimal 
      model of gene-environment interaction was a three-factor interaction model 
      including history of hypertension, history of CHD and rs1801133. Folate 
      supplementation can effectively decrease Hcy level. However, almost half of HHcy 
      patients failed to reach the normal range. The efficacy of folate therapy may be 
      genetically regulated.
FAU - Du, Binghui
AU  - Du B
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Tian, Huizi
AU  - Tian H
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Tian, Dandan
AU  - Tian D
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Zhang, Chengda
AU  - Zhang C
AD  - 2Department of Biostatistics and Bioinformatics,School of Public Health and 
      Tropical Medicine,Tulane University,New Orleans,LA 70112,USA.
FAU - Wang, Wenhua
AU  - Wang W
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Wang, Lianke
AU  - Wang L
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Ge, Mengying
AU  - Ge M
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Hou, Quanliang
AU  - Hou Q
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
FAU - Zhang, Weidong
AU  - Zhang W
AD  - 1Department of Epidemiology,School of Public Health,Zhengzhou 
      University,Zhengzhou 450001,Henan,People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Folic Acid/*metabolism/*therapeutic use
MH  - Gene Expression Regulation
MH  - Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Hyperhomocysteinemia/*drug therapy/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
OTO - NOTNLM
OT  - HHcy hyperhomocysteinaemia
OT  - Hcy homocysteine
OT  - Efficacy
OT  - Folate
OT  - Gene polymorphisms
OT  - Hyperhomocysteinaemia
EDAT- 2018/04/13 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/04/13 06:00
PHST- 2018/04/13 06:00 [entrez]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
AID - S0007114518000508 [pii]
AID - 10.1017/S0007114518000508 [doi]
PST - ppublish
SO  - Br J Nutr. 2018 Apr;119(8):887-895. doi: 10.1017/S0007114518000508.