PMID- 29645082
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20240328
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 193
IP  - 2
DP  - 2018 Aug
TI  - Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of 
      asthmatic children.
PG  - 207-220
LID - 10.1111/cei.13135 [doi]
AB  - Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 
      25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with 
      asthma. Here, we investigated the innate immune responses to RV and their 
      possible modulation by 25(OH)-VitD3 serum levels in a preschool cohort of 
      children with and without asthma. The innate lymphoid cell type 2 
      (ILC2)-associated marker, ST2, was found up-regulated in the blood cells of 
      asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of RV in 
      their airways. Furthermore, in blood cells from control and asthmatic children 
      with RV in their airways, soluble (s) ST2 (sST2) protein was found reduced. 
      Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their 
      airways at the time of the analysis had the lowest sST2 protein levels in the 
      peripheral blood compared to control children without RV and high levels of 
      25(OH)-VitD3. Amphiregulin (AREG), another ILC2-associated marker, was found 
      induced in the control children with RV in their airways and low serum levels of 
      25(OH)-VitD3. In conclusion, the anti-inflammatory soluble form of ST2, also 
      known as sST2, in serum correlated directly with interleukin (IL)-33 in the 
      airways of asthmatic children. Furthermore, RV colonization in the airways and 
      low serum levels of 25(OH)-VitD3 were found to be associated with down-regulation 
      of sST2 in serum in paediatric asthma. These data indicate a counter-regulatory 
      role of 25(OH)-VitD3 on RV-induced down-regulation of serum sST2 in paediatric 
      asthma, which is relevant for the therapy of this disease.
CI  - (c) 2018 British Society for Immunology.
FAU - Haag, P
AU  - Haag P
AD  - Department of Molecular Pneumology, Friedrich-Alexander-Universitat (FAU) 
      Erlangen-Nurnberg, Universitatsklinikum Erlangen, Erlangen, Germany.
FAU - Sharma, H
AU  - Sharma H
AD  - Translational Genomics Core, Partners Biobank, Partners HealthCare, Personalized 
      Medicine, Cambridge, MA, USA.
FAU - Rauh, M
AU  - Rauh M
AD  - Department of Allergy and Pneumology, Children's Hospital, 
      Friedrich-Alexander-Universitat (FAU) Erlangen-Nurnberg, Universitatsklinikum 
      Erlangen, Erlangen, Germany.
FAU - Zimmermann, T
AU  - Zimmermann T
AD  - Department of Allergy and Pneumology, Children's Hospital, 
      Friedrich-Alexander-Universitat (FAU) Erlangen-Nurnberg, Universitatsklinikum 
      Erlangen, Erlangen, Germany.
FAU - Vuorinen, T
AU  - Vuorinen T
AD  - Department of Virology, University of Turku, Turku, Finland.
FAU - Papadopoulos, N G
AU  - Papadopoulos NG
AD  - Allergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and 
      Kapodistria, University of Athens, Athens, Greece.
FAU - Weiss, S T
AU  - Weiss ST
AD  - Translational Genomics Core, Partners Biobank, Partners HealthCare, Personalized 
      Medicine, Cambridge, MA, USA.
FAU - Finotto, S
AU  - Finotto S
AUID- ORCID: 0000-0001-7623-7977
AD  - Department of Molecular Pneumology, Friedrich-Alexander-Universitat (FAU) 
      Erlangen-Nurnberg, Universitatsklinikum Erlangen, Erlangen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180531
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (IL1RL1 protein, human)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
RN  - 0 (Interleukin-33)
RN  - 1C6V77QF41 (Cholecalciferol)
SB  - IM
MH  - Asthma/*immunology
MH  - Cells, Cultured
MH  - Child
MH  - Child, Preschool
MH  - Cholecalciferol/*blood
MH  - Cohort Studies
MH  - Common Cold/*immunology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunity, Innate
MH  - Interleukin-1 Receptor-Like 1 Protein/genetics/*metabolism
MH  - Interleukin-33/metabolism
MH  - Leukocytes, Mononuclear/*physiology/virology
MH  - Male
MH  - Respiratory System/*metabolism
MH  - Rhinovirus/*immunology
MH  - Up-Regulation
PMC - PMC6046486
OTO - NOTNLM
OT  - ILC2
OT  - amphiregulin (AREG)
OT  - paediatric asthma
OT  - rhinovirus
OT  - vitamin D3
EDAT- 2018/04/13 06:00
MHDA- 2019/07/02 06:00
PMCR- 2019/08/01
CRDT- 2018/04/13 06:00
PHST- 2018/04/05 00:00 [accepted]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2018/04/13 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - CEI13135 [pii]
AID - 10.1111/cei.13135 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2018 Aug;193(2):207-220. doi: 10.1111/cei.13135. Epub 2018 May 
      31.