PMID- 29648487 OWN - NLM STAT- MEDLINE DCOM- 20181105 LR - 20190318 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) VI - 21 IP - 7 DP - 2018 Oct TI - BDNF expression increases without changes in play behavior following concussion in juvenile rats (Rattus Norvegicus). PG - 475-479 LID - 10.1080/17518423.2018.1460878 [doi] AB - PURPOSE: Young children have a high risk of concussion or mild traumatic brain injury (mTBI). Children often appear healthy soon after mTBI, but some have pervasive cognitive and/or motor impairments. Understanding underlying mechanisms recruited after concussion may help for return to play protocols and mitigating what might be lifelong impairments. METHODS: We investigated molecular and behavioral changes in a rat model of childhood concussion. Rats received an injury or sham procedure at an age approximately equivalent to the human period of early childhood. Social play was analyzed for behavioral differences. Tissue from the right motor cortex (impacted), left motor cortex, and medial prefrontal cortex were analyzed for brain derived neurotrophic factor (BDNF) protein. RESULTS: Play behavior was not significantly different between conditions. BDNF levels were much higher in both the right and left motor cortices of the mTBI group compared to medial prefrontal cortex, which is relatively remote from the impact site, within the mTBI group and all tissue collected from the sham group. CONCLUSIONS: There is ongoing plastic change at the cellular level in both the impacted area and the well-connected contralateral area after a concussion, suggesting compensatory mechanisms after injury are still at play. FAU - Dyck, Allison C F AU - Dyck ACF AD - a Department of Psychology , University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Ivanco, Tammy L AU - Ivanco TL AUID- ORCID: 0000-0002-5215-172X AD - a Department of Psychology , University of Manitoba, Winnipeg, Manitoba, Canada. AD - b Childrens Hospital Research Foundation of Manitoba , Winnipeg , Manitoba , Canada. LA - eng PT - Journal Article DEP - 20180412 PL - England TA - Dev Neurorehabil JT - Developmental neurorehabilitation JID - 101304394 RN - 0 (Bdnf protein, rat) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Behavior, Animal MH - Brain Concussion/*metabolism/*psychology MH - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics MH - Motor Cortex/metabolism MH - Neuronal Plasticity MH - Play and Playthings/*psychology MH - Prefrontal Cortex/metabolism MH - Rats MH - Rats, Long-Evans MH - Social Behavior OTO - NOTNLM OT - Brain Derived Neurotrophic Factor OT - development OT - mild traumatic brain injury OT - pediatric injury OT - social play EDAT- 2018/04/13 06:00 MHDA- 2018/11/06 06:00 CRDT- 2018/04/13 06:00 PHST- 2018/04/13 06:00 [pubmed] PHST- 2018/11/06 06:00 [medline] PHST- 2018/04/13 06:00 [entrez] AID - 10.1080/17518423.2018.1460878 [doi] PST - ppublish SO - Dev Neurorehabil. 2018 Oct;21(7):475-479. doi: 10.1080/17518423.2018.1460878. Epub 2018 Apr 12.