PMID- 29648777
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20190221
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 10
IP  - 25
DP  - 2018 Jun 27
TI  - Applications of Light-Responsive Systems for Cancer Theranostics.
PG  - 21021-21034
LID - 10.1021/acsami.8b01114 [doi]
AB  - Achieving controlled and targeted delivery of chemotherapeutic drugs and other 
      therapeutic agents to tumor sites is challenging. Among many stimulus strategies, 
      light as a mode of action shows various advantages such as high spatiotemporal 
      selectivity, minimal invasiveness and easy operation. Thus, drug delivery systems 
      (DDSs) have been designed with the incorporation of various functionalities 
      responsive to light as an exogenous stimulus. Early development has focused on 
      guiding chemotherapeutic drugs to designated location, followed by the 
      utilization of UV irradiation for controlled drug release. Because of the 
      disadvantages of UV light such as phototoxicity and limited tissue penetration 
      depth, scientists have moved the research focus onto developing nanoparticle 
      systems responsive to light in the visible region (400-700 nm), aiming to reduce 
      the phototoxicity. In order to enhance the tissue penetration depth, 
      near-infrared light triggered DDSs become increasingly important. In addition, 
      light-based advanced systems for fluorescent and photoacoustic imaging, as well 
      as photodynamic and photothermal therapy have also been reported. Herein, we 
      highlight some of recent developments by applying light-responsive systems in 
      cancer theranostics, including light activated drug release, photodynamic and 
      photothermal therapy, and bioimaging techniques such as fluorescent and 
      photoacoustic imaging. Future prospect of light-mediated cancer treatment is 
      discussed at the end of the review. This Spotlights on Applications article aims 
      to provide up-to-date information about the rapidly developing field of 
      light-based cancer theranostics.
FAU - Chen, Hongzhong
AU  - Chen H
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , 
      Singapore 637371.
FAU - Zhao, Yanli
AU  - Zhao Y
AUID- ORCID: 0000-0002-9231-8360
AD  - Division of Chemistry and Biological Chemistry, School of Physical and 
      Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , 
      Singapore 637371.
AD  - School of Materials Science and Engineering , Nanyang Technological University , 
      50 Nanyang Avenue , Singapore 639798.
LA  - eng
PT  - Journal Article
DEP - 20180419
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
SB  - IM
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Infrared Rays
MH  - Nanoparticles
MH  - Neoplasms
MH  - Theranostic Nanomedicine
OTO - NOTNLM
OT  - cancer theranostics
OT  - fluorescence imaging
OT  - light activated therapy
OT  - photoacoustic imaging
OT  - photodynamic therapy
OT  - photothermal therapy
EDAT- 2018/04/13 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/04/13 06:00
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/04/13 06:00 [entrez]
AID - 10.1021/acsami.8b01114 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2018 Jun 27;10(25):21021-21034. doi: 
      10.1021/acsami.8b01114. Epub 2018 Apr 19.