PMID- 29649487
OWN - NLM
STAT- MEDLINE
DCOM- 20190222
LR  - 20190222
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 676
DP  - 2018 May 29
TI  - Expression patterns and role of PTEN in rat peripheral nerve development and 
      injury.
PG  - 78-84
LID - S0304-3940(18)30277-5 [pii]
LID - 10.1016/j.neulet.2018.04.016 [doi]
AB  - Studies have suggested that phosphatase and tensin homolog (PTEN) plays an 
      important role in neuroprotection and neuronal regeneration. To better understand 
      the potential role of PTEN with respect to peripheral nerve development and 
      injury, we investigated the expression pattern of PTEN at different stages of rat 
      peripheral nerve development and injury and subsequently assessed the effect of 
      pharmacological inhibition of PTEN using bpV(pic) on axonal regeneration in a rat 
      sciatic nerve crush injury model. During the early stages of development, PTEN 
      exhibits low expression in neuronal cell bodies and axons. From embryonic day (E) 
      18.5 and postnatal day (P)5 to adult, PTEN protein becomes more detectable, with 
      high expression in the dorsal root ganglia (DRG) and axons. PTEN expression is 
      inhibited in peripheral nerves, preceding myelination during neuronal development 
      and remyelination after acute nerve injury. Low PTEN expression after nerve 
      injury promotes Akt/mammalian target of rapamycin (mTOR) signaling pathway 
      activity. In vivo pharmacological inhibition of PTEN using bpV(pic) promoted 
      axonal regrowth, increased the number of myelinated nerve fibers, improved 
      locomotive recovery and enhanced the amplitude response and nerve conduction 
      velocity following stimulation in a rat sciatic nerve crush injury model. Thus, 
      we suggest that PTEN may play potential roles in peripheral nerve development and 
      regeneration and that inhibition of PTEN expression is beneficial for nerve 
      regeneration and functional recovery after peripheral nerve injury.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Chen, Hui
AU  - Chen H
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Xiang, Jianping
AU  - Xiang J
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Wu, Junxia
AU  - Wu J
AD  - Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, PR China.
FAU - He, Bo
AU  - He B
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Lin, Tao
AU  - Lin T
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Zhu, Qingtang
AU  - Zhu Q
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Liu, Xiaolin
AU  - Liu X
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China.
FAU - Zheng, Canbin
AU  - Zheng C
AD  - Department of Orthopedic and Microsurgery, The First Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, PR China. Electronic address: zhengcanbin@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180409
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (Pten protein, rat)
SB  - IM
MH  - Animals
MH  - Ganglia, Spinal/metabolism
MH  - Nerve Crush
MH  - *Nerve Regeneration
MH  - PTEN Phosphohydrolase/*metabolism
MH  - Peripheral Nerve Injuries/*metabolism
MH  - Peripheral Nerves/*embryology/*metabolism
MH  - Rats
MH  - Sciatic Nerve/injuries/physiopathology
OTO - NOTNLM
OT  - Crush injury
OT  - Development
OT  - PTEN
OT  - Peripheral nerve
OT  - Regeneration
EDAT- 2018/04/13 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/04/13 06:00
PHST- 2018/02/24 00:00 [received]
PHST- 2018/03/29 00:00 [revised]
PHST- 2018/04/07 00:00 [accepted]
PHST- 2018/04/13 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/04/13 06:00 [entrez]
AID - S0304-3940(18)30277-5 [pii]
AID - 10.1016/j.neulet.2018.04.016 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 May 29;676:78-84. doi: 10.1016/j.neulet.2018.04.016. Epub 
      2018 Apr 9.