PMID- 29650413
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20181001
IS  - 1873-5800 (Electronic)
IS  - 0968-0160 (Linking)
VI  - 25
IP  - 3
DP  - 2018 Jun
TI  - Taurine protects against knee osteoarthritis development in experimental rat 
      models.
PG  - 374-380
LID - S0968-0160(18)30104-2 [pii]
LID - 10.1016/j.knee.2018.03.004 [doi]
AB  - BACKGROUND: Osteoarthritis (OA) is one of the complex diseases that affect a 
      large population of the world. The aim of the current study was to explore the 
      roles of taurine in OA rat models, and discover the related mechanisms. METHODS: 
      OA rat models were established by anterior cruciate ligament transection (ACLT) 
      plus medial meniscus resection (MMx) surgery on the right knees. Secondary 
      mechanical allodynia, weight-bearing alterations and knee joint width were 
      evaluated before surgery and every two weeks after surgery. At 14weeks, 
      histopathological analysis was conducted on the knee joint cartilage. Protein 
      amount of MMP-3 and CHOP was evaluated by western blot. RESULTS: Taurine 
      injection after surgery significantly relieved the symptoms of OA in rat models 
      in a dose-dependent and time-dependent manner, as shown by alleviation of 
      secondary mechanical allodynia, decrease in hind limb weight-bearing alterations, 
      and inhibited knee swelling. Moreover, histopathological analysis showed that 
      taurine inhibited matrix loss and cartilage degeneration in a dose-dependent 
      manner. Taurine administration strikingly suppressed the expression of matrix 
      metalloproteinase-3 (MMP-3) and CHOP. CONCLUSION: These results indicated that 
      taurine administration exhibited protective effects by inhibiting MMP-3 and CHOP 
      expression, and subsequently alleviated the OA symptoms in experimental rat 
      models.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bian, Yiqun
AU  - Bian Y
AD  - Liaocheng People's Hospital, Liaocheng, Shandong, China.
FAU - Zhang, Meng
AU  - Zhang M
AD  - Liaocheng People's Hospital, Liaocheng, Shandong, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Liaocheng People's Hospital, Liaocheng, Shandong, China. Electronic address: 
      wangkaisdlc@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180409
PL  - Netherlands
TA  - Knee
JT  - The Knee
JID - 9430798
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Cartilage Diseases/*drug therapy/pathology
MH  - Cartilage, Articular/drug effects/pathology
MH  - Disease Models, Animal
MH  - Knee Joint/drug effects/pathology
MH  - Male
MH  - Osteoarthritis, Knee/*drug therapy/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Taurine/*therapeutic use
OTO - NOTNLM
OT  - Anterior cruciate ligament transection plus medial meniscus resection surgery 
      (ACLT plus MMx)
OT  - CHOP
OT  - Matrix metalloproteinase-3 (MMP-3)
OT  - Osteoarthritis
OT  - Osteoarthritis rat model
OT  - Taurine
EDAT- 2018/04/14 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/04/14 06:00
PHST- 2017/12/24 00:00 [received]
PHST- 2018/02/06 00:00 [revised]
PHST- 2018/03/06 00:00 [accepted]
PHST- 2018/04/14 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/14 06:00 [entrez]
AID - S0968-0160(18)30104-2 [pii]
AID - 10.1016/j.knee.2018.03.004 [doi]
PST - ppublish
SO  - Knee. 2018 Jun;25(3):374-380. doi: 10.1016/j.knee.2018.03.004. Epub 2018 Apr 9.