PMID- 29651308
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1759-9660 (Print)
IS  - 1759-9679 (Electronic)
IS  - 1759-9660 (Linking)
VI  - 9
IP  - 34
DP  - 2017
TI  - DART-MS analysis of inorganic explosives using high temperature thermal 
      desorption.
PG  - 4988-4996
LID - 10.1039/C7AY00867H [doi]
AB  - An ambient mass spectrometry (MS) platform coupling resistive Joule heating 
      thermal desorption (JHTD) and direct analysis in real time (DART) was implemented 
      for the analysis of inorganic nitrite, nitrate, chlorate, and perchlorate salts. 
      The resistive heating component generated discrete and rapid heating ramps and 
      elevated temperatures, up to approximately 400  degrees C s(-1) and 750  degrees C, by passing a 
      few amperes of DC current through a nichrome wire. JHTD enhanced the utility and 
      capabilities of traditional DART-MS for the trace detection of previously 
      difficult to detect inorganic compounds. A partial factorial design of 
      experiments (DOE) was implemented for the systematic evaluation of five system 
      parameters. A base set of conditions for JHTD-DART-MS was derived from this 
      evaluation, demonstrating sensitive detection of a range of inorganic oxidizer 
      salts, down to single nanogram levels. DOE also identified JHTD filament current 
      and in-source collision induced dissociation (CID) energy as inducing the 
      greatest effect on system response. Tuning of JHTD current provided a method for 
      controlling the relative degrees of thermal desorption and thermal decomposition. 
      Furthermore, in-source CID provided manipulation of adduct and cluster 
      fragmentation, optimizing the detection of molecular anion species. Finally, the 
      differential thermal desorption nature of the JHTD-DART platform demonstrated 
      efficient desorption and detection of organic and inorganic explosive mixtures, 
      with each desorbing at its respective optimal temperature.
FAU - Forbes, Thomas P
AU  - Forbes TP
AD  - National Institute of Standards and Technology, Materials Measurement Science 
      Division, Gaithersburg, MD, USA.
FAU - Sisco, Edward
AU  - Sisco E
AD  - National Institute of Standards and Technology, Materials Measurement Science 
      Division, Gaithersburg, MD, USA.
FAU - Staymates, Matthew
AU  - Staymates M
AD  - National Institute of Standards and Technology, Materials Measurement Science 
      Division, Gaithersburg, MD, USA.
FAU - Gillen, Greg
AU  - Gillen G
AD  - National Institute of Standards and Technology, Materials Measurement Science 
      Division, Gaithersburg, MD, USA.
LA  - eng
GR  - 9999-NIST/Intramural NIST DOC/United States
PT  - Journal Article
DEP - 20170504
PL  - England
TA  - Anal Methods
JT  - Analytical methods : advancing methods and applications
JID - 101519733
PMC - PMC5890339
MID - NIHMS915369
EDAT- 2017/01/01 00:00
MHDA- 2017/01/01 00:01
PMCR- 2018/05/04
CRDT- 2018/04/14 06:00
PHST- 2018/04/14 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2017/01/01 00:01 [medline]
PHST- 2018/05/04 00:00 [pmc-release]
AID - 10.1039/C7AY00867H [doi]
PST - ppublish
SO  - Anal Methods. 2017;9(34):4988-4996. doi: 10.1039/C7AY00867H. Epub 2017 May 4.