PMID- 29651327
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20220317
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2018
DP  - 2018
TI  - Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: 
      Is Upper Tract Urine More Accurate than Urine from the Bladder?
PG  - 5823870
LID - 10.1155/2018/5823870 [doi]
LID - 5823870
AB  - OBJECTIVES: To assess the performance of urine markers determined in urine 
      samples from the bladder compared to samples collected from the upper urinary 
      tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). PATIENTS AND METHODS: 
      The study comprised 758 urine samples either collected from the bladder (n = 373) 
      or UUT (n = 385). All patients underwent urethrocystoscopy and UUT imaging or 
      ureterorenoscopy. Cytology, fluorescence in situ hybridization (FISH), 
      immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed. 
      RESULTS: UUT UC was diagnosed in 59 patients (19.1%) (UUT urine) and 27 patients 
      (7.2%) (bladder-derived urine). For UUT-derived samples, sensitivities for 
      cytology, FISH, NMP22, and uCyt+ were 74.6, 79.0, 100.0, and 100.0, while 
      specificities were 66.6, 50.7, 5.9, and 66.7%, respectively. In bladder-derived 
      samples, sensitivities were 59.3, 52.9, 62.5, and 50.0% whereas specificities 
      were 82.9, 85.0, 31.3, and 69.8%. In UUT-derived samples, concomitant bladder 
      cancer led to increased false-positive rates of cytology and FISH. CONCLUSIONS: 
      Urine markers determined in urine collected from the UUT exhibit better 
      sensitivity but lower specificity compared to markers determined in 
      bladder-derived urine. Concomitant or recent diagnosis of UC of the bladder can 
      further influence markers determined in UUT urine.
FAU - Bier, Simone
AU  - Bier S
AUID- ORCID: 0000-0003-0189-1119
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Hennenlotter, Jorg
AU  - Hennenlotter J
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Esser, Michael
AU  - Esser M
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Mohrhardt, Sarah
AU  - Mohrhardt S
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Rausch, Steffen
AU  - Rausch S
AUID- ORCID: 0000-0002-6398-8701
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Schwentner, Christian
AU  - Schwentner C
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Maas, Moritz
AU  - Maas M
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Deininger, Susanne
AU  - Deininger S
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Walz, Simon
AU  - Walz S
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Bedke, Jens
AU  - Bedke J
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Stenzl, Arnulf
AU  - Stenzl A
AUID- ORCID: 0000-0003-4207-9928
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
FAU - Todenhofer, Tilman
AU  - Todenhofer T
AUID- ORCID: 0000-0003-4432-2741
AD  - Department of Urology, Eberhard Karls University, Tuebingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180130
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Nuclear Proteins)
RN  - 0 (nuclear matrix protein 22)
SB  - IM
MH  - Biomarkers, Tumor/*urine
MH  - Carcinoma, Transitional Cell/*diagnosis/metabolism/urine
MH  - Cystoscopy
MH  - Early Detection of Cancer/*methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Nuclear Proteins/metabolism
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Ureteroscopy
MH  - Urologic Neoplasms/*diagnosis/metabolism/urine
PMC - PMC5831978
EDAT- 2018/04/14 06:00
MHDA- 2018/09/11 06:00
PMCR- 2018/01/30
CRDT- 2018/04/14 06:00
PHST- 2017/08/13 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/04/14 06:00 [entrez]
PHST- 2018/04/14 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/01/30 00:00 [pmc-release]
AID - 10.1155/2018/5823870 [doi]
PST - epublish
SO  - Dis Markers. 2018 Jan 30;2018:5823870. doi: 10.1155/2018/5823870. eCollection 
      2018.