PMID- 29651528
OWN - NLM
STAT- MEDLINE
DCOM- 20180629
LR  - 20180629
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 410
IP  - 16
DP  - 2018 Jun
TI  - Ternary mixed-mode silica sorbent of solid-phase extraction for determination of 
      basic, neutral and acidic drugs in human serum.
PG  - 3731-3742
LID - 10.1007/s00216-018-1037-3 [doi]
AB  - In this study, a ternary mixed-mode silica sorbent (TMSS) with octamethylene, 
      carboxyl, and amino groups was prepared via Cu(I)-catalyzed azide-alkyne 
      cycloaddition (CuAAC) click reaction and a subsequent reduction of azide to 
      primary amine. While used in solid-phase extraction (SPE), the retention behavior 
      of TMSS towards a total of nine kinds of basic, neutral, and acidic drugs was 
      investigated in detail. The results revealed that hydrophobic, ion-exchange 
      interaction, and electrostatic repulsion between TMSS and the analytes were 
      closely related to the retention behavior of TMSS. Besides, the log K(ow) value 
      of the analyte was also a factor influencing the retention behavior of analytes 
      on TMSS. The nine analytes could be retained by TMSS simultaneously and then, 
      were eluted into two fractions according to the acid-base property of the 
      analytes for further determinations. The acidic and neutral analytes were in one 
      fraction, and the basic ones in the other fraction. When used to treat the human 
      serum spiked with the nine drugs, TMSS offered higher recoveries than BakerBond 
      CBA and comparable recoveries to Oasis WCX. It should be noted TMSS had better 
      purifying capability for human serum than Oasis WCX. Under the optimized SPE 
      conditions, a method of SPE hyphenated to high-performance liquid 
      chromatography-ultraviolet detection (HPLC-UV) for determination of the basic, 
      neutral, and acidic drugs spiked in human serum was established. For the nine 
      drugs, the linear ranges were all between 5.0 and 1000 mug L(-1) with correlation 
      coefficients (R(2)) above 0.9990, and the limits of detection (LODs) were in the 
      range of 0.8-2.3 mug L(-1). The intra-day and inter-day relative standard 
      deviations (RSDs) were less than 5.3 and 8.8%, respectively. Graphical abstract 
      Treating drugs in human serum by SPE with ternary mixed-mode silica sorbent.
FAU - Jin, Shupei
AU  - Jin S
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan, 430072, Hubei, 
      China.
AD  - Kaifeng Inspection Center for Agricultural Products Safety and Quality, Kaifeng, 
      475000, Henan, China.
FAU - Qiao, Yinghua
AU  - Qiao Y
AD  - Guangdong Communication Polytechnic Education Center, Guangzhou, 510650, 
      Guangdong, China.
FAU - Xing, Jun
AU  - Xing J
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan, 430072, Hubei, 
      China. gc-ms@263.net.
LA  - eng
PT  - Journal Article
DEP - 20180413
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Pharmaceutical Preparations)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Adsorption
MH  - Amination
MH  - Chromatography, High Pressure Liquid/methods
MH  - Click Chemistry
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Limit of Detection
MH  - Pharmaceutical Preparations/*blood/*isolation & purification
MH  - Silicon Dioxide/*chemistry
MH  - Solid Phase Extraction/*methods
OTO - NOTNLM
OT  - Click reaction
OT  - Drugs
OT  - HPLC-UV
OT  - Human serum
OT  - Solid-phase extraction
OT  - Ternary mixed-mode silica sorbent
EDAT- 2018/04/14 06:00
MHDA- 2018/06/30 06:00
CRDT- 2018/04/14 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/02/13 00:00 [revised]
PHST- 2018/04/14 06:00 [pubmed]
PHST- 2018/06/30 06:00 [medline]
PHST- 2018/04/14 06:00 [entrez]
AID - 10.1007/s00216-018-1037-3 [pii]
AID - 10.1007/s00216-018-1037-3 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2018 Jun;410(16):3731-3742. doi: 10.1007/s00216-018-1037-3. 
      Epub 2018 Apr 13.