PMID- 29652115
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20221207
IS  - 1827-1634 (Electronic)
IS  - 0391-1977 (Linking)
VI  - 45
IP  - 1
DP  - 2020 Mar
TI  - Analysis on influencing factors of abnormal renal function in elderly patients 
      with type 2 diabetes mellitus.
PG  - 12-17
LID - 10.23736/S0391-1977.18.02832-8 [doi]
AB  - BACKGROUND: To investigate the related influencing factors of abnormal renal 
      function in elderly in patients with type 2 diabetes mellitus (T2DM) and their 
      clinical significance. METHODS: The clinical data of elderly T2DM patients 
      hospitalized in Beijing Luhe Hospital from January 2013 to June 2016 were 
      retrospectively analyzed. According to their glomerular filtration rate (GFR) 
      levels, these patients were divided into GFR>/=90 mL/min/1.73 m2 group (group A), 
      GFR =60-90 mL/min/1.73 m2 group (group B), and GFR <60 mL/min/1.73 m2 group 
      (group C, i.e., abnormal renal function group). Clinical and laboratory 
      indicators were compared among each group. RESULTS: A total of 614 elderly T2DM 
      patients were collected and divided into group A (N.=186), group B (N.=280) and 
      group C (N.=148, 24.10%). Among them, patients clinically diagnosed with diabetic 
      nephropathy (DN) accounted for 13.68%, and those complicated with high blood 
      pressure (HBP) accounted for 61.40%. In Group C, DN accounted for only 29.73%. In 
      elderly T2DM patients, HBP course, systolic blood pressure (SBP), diastolic blood 
      pressure (DBP), 2h postprandial blood glucose (2hPBG), serum total cholesterol 
      (TC) and blood uric acid (BUA) were independent influencing factors associated 
      with abnormal renal function, among which HBP had a more significant impact on 
      abnormal renal function. With the increase of blood pressure (BP) level, the 
      extension in the course of DM, the increase in urinary albumin/creatinine 
      (Alb/Cr) and the decrease in GFR, the incidence rate of abnormal renal function 
      was increased. CONCLUSIONS: HBP course, SBP, DBP, 2hPBG, TC and BUA are 
      independent risk factors for abnormal renal function in elderly patients with 
      T2DM. Well-controlled BP and blood glucose are protective factors, and a 
      comprehensive treatment targeting to the above influencing factors has important 
      clinical significance in preventing and delaying the occurrence and development 
      of abnormal renal function.
FAU - Chai, Tao
AU  - Chai T
AD  - Department of Nephrology, Beijing Luhe Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Dawei
AU  - Zhang D
AD  - Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, 
      Beijing, China.
FAU - Li, Zhongxin
AU  - Li Z
AD  - Department of Nephrology, Beijing Luhe Hospital, Capital Medical University, 
      Beijing, China - 1969634531@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20180412
PL  - Italy
TA  - Minerva Endocrinol
JT  - Minerva endocrinologica
JID - 8406505
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 268B43MJ25 (Uric Acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Albuminuria/etiology
MH  - Blood Glucose/analysis
MH  - Cholesterol/blood
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Nephropathies/*physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypertension/complications
MH  - *Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Uric Acid/blood
EDAT- 2018/04/14 06:00
MHDA- 2021/01/20 06:00
CRDT- 2018/04/14 06:00
PHST- 2018/04/14 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2018/04/14 06:00 [entrez]
AID - S0391-1977.18.02832-8 [pii]
AID - 10.23736/S0391-1977.18.02832-8 [doi]
PST - ppublish
SO  - Minerva Endocrinol. 2020 Mar;45(1):12-17. doi: 10.23736/S0391-1977.18.02832-8. 
      Epub 2018 Apr 12.