PMID- 29652210
OWN - NLM
STAT- MEDLINE
DCOM- 20200207
LR  - 20200207
IS  - 1744-5078 (Electronic)
IS  - 0927-3948 (Linking)
VI  - 27
IP  - 6
DP  - 2019
TI  - Idiopathic Central Nervous System Inflammatory Disease in the Setting of HLA-B27 
      Uveitis.
PG  - 912-917
LID - 10.1080/09273948.2018.1449865 [doi]
AB  - Purpose: The purpose of the article is to describe a novel case of idiopathic 
      central nervous system inflammatory disease with bilateral human leukocyte 
      antigen (HLA)-B27-positive anterior uveitis. Methods/Results: A 15-year-old 
      African American boy with bilateral HLA-B27-positive anterior uveitis controlled 
      with topical and oral steroids for 8 months acutely developed headaches, left 
      eyelid ptosis, and binocular diplopia. Imaging showed lesions in the right 
      midbrain, superior colliculus, cerebellar peduncles, and cerebellar vermis and 
      leptomeningeal enhancement along the vermian foliae. Cerebral spinal fluid tests 
      showed mild lymphohistiocytic pleocytosis with negative cytology; inflammatory 
      and infectious workup were negative. He received intravenous methylprednisolone 
      without initial symptomatic improvement; repeat magnetic resonance imaging (MRI) 
      showed reduced lesion burden. Oral steroids were continued; his symptoms resolved 
      in 1 month. Repeat MRI 2 months after presentation showed almost complete lesion 
      resolution. Conclusions: Chronic lymphocytic inflammation with pontine 
      perivascular enhancement responsive to steroids (CLIPPERS) was diagnosed. HLA-B27 
      positivity may represent a novel association with CLIPPERS.
FAU - Crowell, Eric L
AU  - Crowell EL
AD  - Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at 
      The University of Texas Health Science Center in Houston (UTHealth) , Houston , 
      Texas , USA.
AD  - Robert Cizik Eye Clinic , Houston , Texas , USA.
FAU - Pfeiffer, Margaret L
AU  - Pfeiffer ML
AD  - Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at 
      The University of Texas Health Science Center in Houston (UTHealth) , Houston , 
      Texas , USA.
AD  - Robert Cizik Eye Clinic , Houston , Texas , USA.
FAU - Kamdar, Ankur A
AU  - Kamdar AA
AD  - Department of Pediatrics, McGovern Medical School at UTHealth , Houston , Texas , 
      USA.
FAU - Koenig, Mary K
AU  - Koenig MK
AD  - Division of Child and Adolescent Neurology, Department of Pediatrics, McGovern 
      Medical School at UTHealth , Houston , Texas , USA.
FAU - Wittenberg, Susan E
AU  - Wittenberg SE
AD  - Houston Eye Associates , Houston , Texas , USA.
FAU - Supsupin, Emilio P
AU  - Supsupin EP
AD  - Department of Diagnostic and Interventional Imaging, McGovern Medical School at 
      UTHealth , Houston , Texas , USA.
FAU - Adesina, Ore-Ofe O
AU  - Adesina OO
AD  - Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at 
      The University of Texas Health Science Center in Houston (UTHealth) , Houston , 
      Texas , USA.
AD  - Robert Cizik Eye Clinic , Houston , Texas , USA.
AD  - Department of Neurology, McGovern Medical School at UTHealth , Houston , Texas , 
      USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180413
PL  - England
TA  - Ocul Immunol Inflamm
JT  - Ocular immunology and inflammation
JID - 9312169
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA-B27 Antigen)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
CIN - Ocul Immunol Inflamm. 2019;27(6):918-919. PMID: 29958047
MH  - Administration, Oral
MH  - Adolescent
MH  - Glucocorticoids/therapeutic use
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Infusions, Intravenous
MH  - Leukocytosis
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningoencephalitis/diagnostic imaging/drug therapy/*immunology
MH  - Methylprednisolone/therapeutic use
MH  - T-Lymphocytes/immunology/*pathology
MH  - Uveitis, Anterior/diagnostic imaging/drug therapy/*immunology
OTO - NOTNLM
OT  - CLIPPERS
OT  - Chronic lymphocytic inflammation with pontine perivascular enhancement responsive 
      to steroids
OT  - HLA-B27
OT  - magnetic resonance imaging
OT  - uveitis
EDAT- 2018/04/14 06:00
MHDA- 2020/02/08 06:00
CRDT- 2018/04/14 06:00
PHST- 2018/04/14 06:00 [pubmed]
PHST- 2020/02/08 06:00 [medline]
PHST- 2018/04/14 06:00 [entrez]
AID - 10.1080/09273948.2018.1449865 [doi]
PST - ppublish
SO  - Ocul Immunol Inflamm. 2019;27(6):912-917. doi: 10.1080/09273948.2018.1449865. 
      Epub 2018 Apr 13.