PMID- 29653348 OWN - NLM STAT- MEDLINE DCOM- 20190104 LR - 20190104 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 264 DP - 2018 Jun TI - Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes. PG - 192-201 LID - S0165-1781(17)31810-3 [pii] LID - 10.1016/j.psychres.2018.03.089 [doi] AB - The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients. 51 bipolar patients were recruited into this study: 34 in the euthymic phase, and 17 in the depressive phase. Our results indicated that the depressive phase could increase the levels of mitochondrial superoxide, carbonyl and TBARS, and superoxide dismutase, and could decrease the levels of mitochondrial complex II activity in the lymphocytes of bipolar patients. It was also observed that there was a negative correlation between the Hamilton Depression Rating Scale (HDRS) and complex II activity in the lymphocytes of depressive bipolar patients. In addition, there was a positive correlation between HDRS and superoxide, superoxide dismutase, TBARS and carbonyl. Additionally, there was a negative correlation between complex II activity and oxidative stress parameters. In conclusion, our results suggest that mitochondrial oxidative stress and mitochondrial complex II dysfunction play important roles in the depressive phase of BD. CI - Copyright (c) 2018. Published by Elsevier B.V. FAU - Valvassori, Samira S AU - Valvassori SS AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. Electronic address: samiravalvassori@unesc.net. FAU - Bavaresco, Daniela V AU - Bavaresco DV AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Feier, Gustavo AU - Feier G AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Cechinel-Recco, Kelen AU - Cechinel-Recco K AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Steckert, Amanda V AU - Steckert AV AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Varela, Roger B AU - Varela RB AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Borges, Cenita AU - Borges C AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Carvalho-Silva, Milena AU - Carvalho-Silva M AD - Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Gomes, Lara M AU - Gomes LM AD - Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Streck, Emilio L AU - Streck EL AD - Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil. FAU - Quevedo, Joao AU - Quevedo J AD - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180404 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Thiobarbituric Acid Reactive Substances) RN - 11062-77-4 (Superoxides) RN - EC 1.15.1.1 (Superoxide Dismutase) SB - IM MH - Adult MH - Bipolar Disorder/*metabolism/psychology MH - Cyclothymic Disorder/blood/metabolism MH - Depression/*metabolism/psychology MH - Female MH - Humans MH - Lymphocytes/*metabolism MH - Male MH - Middle Aged MH - Mitochondria/*metabolism MH - Oxidation-Reduction MH - Oxidative Stress/*physiology MH - Superoxide Dismutase/metabolism MH - Superoxides/metabolism MH - Thiobarbituric Acid Reactive Substances/metabolism OTO - NOTNLM OT - Bipolar disorder OT - Depression OT - Mitochondria OT - Oxidative stress EDAT- 2018/04/14 06:00 MHDA- 2019/01/05 06:00 CRDT- 2018/04/14 06:00 PHST- 2017/10/02 00:00 [received] PHST- 2018/02/19 00:00 [revised] PHST- 2018/03/31 00:00 [accepted] PHST- 2018/04/14 06:00 [pubmed] PHST- 2019/01/05 06:00 [medline] PHST- 2018/04/14 06:00 [entrez] AID - S0165-1781(17)31810-3 [pii] AID - 10.1016/j.psychres.2018.03.089 [doi] PST - ppublish SO - Psychiatry Res. 2018 Jun;264:192-201. doi: 10.1016/j.psychres.2018.03.089. Epub 2018 Apr 4.