PMID- 29653868
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 47
IP  - 7
DP  - 2018 Jul
TI  - Clinicopathological investigation of odontogenic fibroma in tuberous sclerosis 
      complex.
PG  - 918-922
LID - S0901-5027(18)30112-7 [pii]
LID - 10.1016/j.ijom.2018.03.025 [doi]
AB  - Tuberous sclerosis complex (TSC) is an autosomal dominant inherited disease 
      characterized by systemic hamartoma and diverse systemic features. TSC1 and TSC2 
      are the causative genes, and mental retardation, epileptic seizures, and facial 
      angiofibroma develop in many patients with the disease. The case of a patient 
      with TSC who developed a central odontogenic fibroma of the mandible is reported 
      here. The patient was a 21-year-old woman who was referred with a swelling of the 
      labial gingiva in the region of the right lower lateral incisor and canine. 
      Dental radiography revealed a multilocular radiolucent region with a clear 
      boundary. The right lower lateral incisor and canine were continuous with the 
      lesion and thus were excised en bloc. The lesion was encapsulated and easily 
      dissected. The diagnosis on immunohistological staining was odontogenic fibroma 
      without an epithelial component. TSC1/2 gene mutation causes abnormal activation 
      of mammalian target of rapamycin (mTOR) downstream of the PI3K-AKT pathway. The 
      odontogenic fibroma in this patient was positive for mTOR, suggesting that the 
      development of the odontogenic fibroma was the result of abnormal activation of 
      mTOR, as in angiofibroma. The clinical course of this patient is presented and 
      the developmental mechanism of central odontogenic fibroma is discussed.
CI  - Copyright (c) 2018 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Musha, A
AU  - Musha A
AD  - Department of Oral and Maxillofacial Surgery/Plastic Surgery, Gunma University 
      Graduate School of Medicine, Gunma, Japan; Department of Radiation Oncology, 
      Gunma University Graduate School of Medicine, Gunma, Japan. Electronic address: 
      musha@gunma-u.ac.jp.
FAU - Yokoo, S
AU  - Yokoo S
AD  - Department of Oral and Maxillofacial Surgery/Plastic Surgery, Gunma University 
      Graduate School of Medicine, Gunma, Japan.
FAU - Takayama, Y
AU  - Takayama Y
AD  - Department of Oral and Maxillofacial Surgery/Plastic Surgery, Gunma University 
      Graduate School of Medicine, Gunma, Japan.
FAU - Sato, H
AU  - Sato H
AD  - Department of Radiation Oncology, Gunma University Graduate School of Medicine, 
      Gunma, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180410
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
SB  - IM
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Female
MH  - Fibroma/diagnostic imaging/*pathology/*surgery
MH  - Humans
MH  - Immunohistochemistry
MH  - Odontogenic Tumors/diagnostic imaging/*pathology/*surgery
MH  - Tuberous Sclerosis/diagnostic imaging/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - mammalian target of rapamycin
OT  - odontogenic fibroma
OT  - tuberous sclerosis complex
EDAT- 2018/04/15 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/04/15 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/02/18 00:00 [revised]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/04/15 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/15 06:00 [entrez]
AID - S0901-5027(18)30112-7 [pii]
AID - 10.1016/j.ijom.2018.03.025 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2018 Jul;47(7):918-922. doi: 
      10.1016/j.ijom.2018.03.025. Epub 2018 Apr 10.