PMID- 29653991
OWN - NLM
STAT- MEDLINE
DCOM- 20190807
LR  - 20220331
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 90
IP  - 20
DP  - 2018 May 15
TI  - Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged 
      adults.
PG  - e1789-e1798
LID - 10.1212/WNL.0000000000005527 [doi]
AB  - OBJECTIVE: To examine in a 3-year brain imaging study the effects of higher vs 
      lower adherence to a Mediterranean-style diet (MeDi) on Alzheimer disease (AD) 
      biomarker changes (brain beta-amyloid load via (11)C-Pittsburgh compound B [PiB] PET 
      and neurodegeneration via (18)F-fluorodeoxyglucose [FDG] PET and structural MRI) 
      in midlife. METHODS: Seventy 30- to 60-year-old cognitively normal participants 
      with clinical, neuropsychological, and dietary examinations and imaging 
      biomarkers at least 2 years apart were examined. These included 34 participants 
      with higher (MeDi+) and 36 with lower (MeDi-) MeDi adherence. Statistical 
      parametric mapping and volumes of interest were used to compare AD biomarkers 
      between groups at cross section and longitudinally. RESULTS: MeDi groups were 
      comparable for clinical and neuropsychological measures. At baseline, compared to 
      the MeDi+ group, the MeDi- group showed reduced FDG-PET glucose metabolism 
      (CMRglc) and higher PiB-PET deposition in AD-affected regions (p < 0.001). 
      Longitudinally, the MeDi--group showed CMRglc declines and PiB increases in these 
      regions, which were greater than those in the MeDi+ group (p(interaction) < 
      0.001). No effects were observed on MRI. Higher MeDi adherence was estimated to 
      provide 1.5 to 3.5 years of protection against AD. CONCLUSION: Lower MeDi 
      adherence was associated with progressive AD biomarker abnormalities in 
      middle-aged adults. These data support further investigation of dietary 
      interventions for protection against brain aging and AD.
CI  - (c) 2018 American Academy of Neurology.
FAU - Berti, Valentina
AU  - Berti V
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Walters, Michelle
AU  - Walters M
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Sterling, Joanna
AU  - Sterling J
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Quinn, Crystal G
AU  - Quinn CG
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Logue, Michelle
AU  - Logue M
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Andrews, Randolph
AU  - Andrews R
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Matthews, Dawn C
AU  - Matthews DC
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Osorio, Ricardo S
AU  - Osorio RS
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Pupi, Alberto
AU  - Pupi A
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Vallabhajosula, Shankar
AU  - Vallabhajosula S
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Isaacson, Richard S
AU  - Isaacson RS
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - de Leon, Mony J
AU  - de Leon MJ
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY.
FAU - Mosconi, Lisa
AU  - Mosconi L
AD  - From the Department of Clinical Pathophysiology (V.B., A.P.), Nuclear Medicine 
      Unit, University of Florence, Italy; Department of Nutrition and Food Studies 
      (M.W., L.M.), New York University Steinhardt School of Culture, Education, and 
      Human Development, NY; Woodrow Wilson School of Public and International Affairs 
      (J.S.), Department of Psychology, Princeton University, NJ; Department of 
      Psychiatry (C.G.Q., M.L., R.S.O., L.M.), New York University School of Medicine, 
      NY; ADM Diagnostics (R.A., D.C.M., M.J.d.L.), Chicago, IL; and Departments of 
      Radiology (S.V.) and Neurology (R.S.I., L.M.), Weill Cornell Medical 
      Center/NewYork-Presbyterian, NY. lim2035@med.cornell.edu.
LA  - eng
GR  - R01 AG035137/AG/NIA NIH HHS/United States
GR  - R01 AG013616/AG/NIA NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - R01 AG057931/AG/NIA NIH HHS/United States
GR  - P01 AG026572/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180413
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
MH  - Adult
MH  - Alzheimer Disease/*diet therapy/*pathology/psychology
MH  - Brain/diagnostic imaging/*metabolism
MH  - *Diet, Mediterranean
MH  - Female
MH  - Fluorodeoxyglucose F18/pharmacokinetics
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography
MH  - Surveys and Questionnaires
PMC - PMC5957301
EDAT- 2018/04/15 06:00
MHDA- 2019/08/08 06:00
PMCR- 2019/05/15
CRDT- 2018/04/15 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/04/15 06:00 [pubmed]
PHST- 2019/08/08 06:00 [medline]
PHST- 2018/04/15 06:00 [entrez]
PHST- 2019/05/15 00:00 [pmc-release]
AID - WNL.0000000000005527 [pii]
AID - NEUROLOGY2017853606 [pii]
AID - 10.1212/WNL.0000000000005527 [doi]
PST - ppublish
SO  - Neurology. 2018 May 15;90(20):e1789-e1798. doi: 10.1212/WNL.0000000000005527. 
      Epub 2018 Apr 13.