PMID- 29654814
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 140
DP  - 2018 Jun
TI  - Cardiovascular outcomes of dipeptidyl peptidase-4 inhibitors in patients with 
      type 2 diabetes on insulin therapy.
PG  - 279-287
LID - S0168-8227(18)30057-3 [pii]
LID - 10.1016/j.diabres.2018.04.012 [doi]
AB  - AIMS: To compare the hazard of cardiovascular diseases between DPP-4 inhibitor 
      users and non-users who were on insulin therapy. METHODS: We conducted a 
      population-based cohort study. 2652 patients with type 2 diabetes mellitus (T2DM) 
      under insulin therapy were enrolled during 1997-2010. The incidence rates per 
      1000 person-years (PYs) of stroke, coronary heart disease (CAD) and heart failure 
      were compared between 1326 DPP-4 inhibitor users and 1326 propensity score 
      matched non-users. Multivariable Cox proportional hazards model was used to 
      evaluate excess risk of the DPP-4 inhibitor non-users. RESULTS: After adjustment 
      of age, gender, comorbidities, drugs used and diabetes duration; the incidence 
      rate per 1000 PYs were 21.70 and 9.88 in DPP-4 inhibitor non-users and users; 
      DPP-4 inhibitor users had lower hazard ratio (HR) of stroke (adjusted HR: 0.59, 
      95% CI: 0.42-0.83, p value: 0.002) compared with non-users. The incidence rates 
      per 1000 PYs of CAD and heart failure of control versus users were 19.85 versus 
      13.54 and 5.56 versus 4.78; the adjusted HRs of CAD and heart failure were 0.86 
      and 1.11. Both were non-significant. CONCLUSION: This nationwide study 
      demonstrated that insulin plus DPP-4 inhibitor users had significantly lower risk 
      of stroke as compared with non-users.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yen, Fu-Shun
AU  - Yen FS
AD  - Dr. Yen's Clinic, No. 15, Shanying Rd., Gueishan Dist., Taoyuan City 33354, 
      Taiwan. Electronic address: yenfushun@gmail.com.
FAU - Chiang, Jen-Huai
AU  - Chiang JH
AD  - Management Office for Health Data, China Medical University Hospital, Taichung, 
      Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. 
      Electronic address: zinvii@gmail.com.
FAU - Pan, Chun-Wei
AU  - Pan CW
AD  - University of the East Ramon Magsaysay Medical Center Inc, 64 Aurora Boulevard, 
      Barangay Dona Imelda, Quezon City 1113, Philippines. Electronic address: 
      wpan931109@gmail.com.
FAU - Lin, Boniface J
AU  - Lin BJ
AD  - Lin Clinic, No. 2, Sec. 2, Xinsheng S. Rd., Da'an Dist., Taipei City 10650, 
      Taiwan. Electronic address: boniface.lin@gmail.com.
FAU - Wei, James Cheng-Chung
AU  - Wei JC
AD  - Institute of Medicine, Chung Shan Medical University, Department of Medicine, 
      Chung Shan Medical University Hospital, Graduate Institute of Integrated 
      Medicine, China Medical University, Taichung, Taiwan. Electronic address: 
      jccwei@gmail.com.
FAU - Hsu, Chih-Cheng
AU  - Hsu CC
AD  - Institute of Population Health Sciences, National Health Research Institutes, 
      Zhunan, Taiwan; Department of Family Medicine, Min-Sheng General Hospital, 
      Taoyuan, Taiwan; Department of Health Services Administration, China Medical 
      University, Taichung, Taiwan. Electronic address: cch@nhri.org.tw.
LA  - eng
PT  - Journal Article
DEP - 20180412
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/*drug therapy/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*drug therapy/pathology
MH  - Dipeptidyl-Peptidase IV Inhibitors/pharmacology/*therapeutic use
MH  - Female
MH  - Heart Failure/epidemiology
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - DPP-4 inhibitors
OT  - Stroke
OT  - Type 2 diabetes mellitus
EDAT- 2018/04/15 06:00
MHDA- 2018/07/26 06:00
CRDT- 2018/04/15 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/03/26 00:00 [revised]
PHST- 2018/04/04 00:00 [accepted]
PHST- 2018/04/15 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
PHST- 2018/04/15 06:00 [entrez]
AID - S0168-8227(18)30057-3 [pii]
AID - 10.1016/j.diabres.2018.04.012 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Jun;140:279-287. doi: 
      10.1016/j.diabres.2018.04.012. Epub 2018 Apr 12.