PMID- 29655945
OWN - NLM
STAT- MEDLINE
DCOM- 20190222
LR  - 20190222
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 676
DP  - 2018 May 29
TI  - Long term Westernized diet leads to region-specific changes in brain signaling 
      mechanisms.
PG  - 85-91
LID - S0304-3940(18)30275-1 [pii]
LID - 10.1016/j.neulet.2018.04.014 [doi]
AB  - Western diets, high in fat and energy, are associated with cognitive deficits in 
      humans and animal models, but the underlying mechanisms are not fully elucidated. 
      This includes whether diet-induced dyslipidemia per se negatively impacts brain 
      signaling. Here we investigate the effects of dyslipidemia induced by two high 
      fat diets with or without high sucrose on hippocampal and frontal cortical 
      oxidative stress, brain-derived neurotrophic factor (BDNF) and down-stream 
      markers of synaptic plasticity, as well as alterations in monoaminergic 
      neurotransmitter levels. A high fat diet was associated with decreased 
      antioxidant status (vitamin C), increased serotonin in the frontal cortex, and 
      increased ratio of phosphorylated Ca(2+)/calmodulin-dependent protein kinase II 
      in the hippocampus, while a high fat and sucrose diet decreased levels of vitamin 
      C in the frontal cortex and BDNF in the hippocampus. Markers of dyslipidemia 
      correlated significantly with cerebral vitamin C levels, monoaminergic 
      neurotransmitters and metabolites in the frontal cortex, but not in the 
      hippocampus. Thus, a high fat diet caused regional alterations in antioxidant 
      levels, neurochemistry and molecular markers in the non-obese dyslipidemic guinea 
      pig.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Hansen, Stine Normann
AU  - Hansen SN
AD  - Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty 
      of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1.Floor, 
      DK-1870 Frederiksberg C, Denmark.
FAU - Ipsen, David Hojland
AU  - Ipsen DH
AD  - Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty 
      of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1.Floor, 
      DK-1870 Frederiksberg C, Denmark.
FAU - Schou-Pedersen, Anne Marie
AU  - Schou-Pedersen AM
AD  - Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty 
      of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1.Floor, 
      DK-1870 Frederiksberg C, Denmark.
FAU - Lykkesfeldt, Jens
AU  - Lykkesfeldt J
AD  - Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty 
      of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1.Floor, 
      DK-1870 Frederiksberg C, Denmark.
FAU - Tveden-Nyborg, Pernille
AU  - Tveden-Nyborg P
AD  - Experimental Animal Models, Department of Veterinary and Animal Sciences, Faculty 
      of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1.Floor, 
      DK-1870 Frederiksberg C, Denmark. Electronic address: ptn@sund.ku.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180412
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Diet, Western/*adverse effects
MH  - Dyslipidemias/etiology/*metabolism
MH  - Female
MH  - Frontal Lobe/*metabolism
MH  - Guinea Pigs
MH  - Hippocampus/*metabolism
MH  - Neuronal Plasticity
MH  - Signal Transduction
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cavia porcellus
OT  - Dyslipidemia
OT  - Monoaminergic neurotransmitters
OT  - Oxidative stress
OT  - Synaptic plasticity
EDAT- 2018/04/16 06:00
MHDA- 2019/02/23 06:00
CRDT- 2018/04/16 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/04/04 00:00 [revised]
PHST- 2018/04/06 00:00 [accepted]
PHST- 2018/04/16 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/04/16 06:00 [entrez]
AID - S0304-3940(18)30275-1 [pii]
AID - 10.1016/j.neulet.2018.04.014 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 May 29;676:85-91. doi: 10.1016/j.neulet.2018.04.014. Epub 
      2018 Apr 12.