PMID- 29656250
OWN - NLM
STAT- MEDLINE
DCOM- 20180829
LR  - 20181202
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 239
DP  - 2018 Aug
TI  - Exposure to environmental level phenanthrene induces a NASH-like phenotype in new 
      born rat.
PG  - 261-271
LID - S0269-7491(17)34956-4 [pii]
LID - 10.1016/j.envpol.2018.04.030 [doi]
AB  - More and more evidence indicates that persistent organic pollutants (POPs) are a 
      risk factor for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic 
      steatohepatitis (NASH). Phenanthrene (Phe) is a kind of POP which existed 
      extensively in the environment, but whose toxicity on mammals has so far received 
      less focus. Subcutaneously injection of Phe (0.5, 5, 50 mug/kg) for 21 days 
      induced significant NAFLD/NASH symptoms in new born rats. Exposure to 
      environmental levels of Phe decreased body weight and liver-somatic index; 
      impaired histology of liver; influenced the peroxisome proliferator-activated 
      receptor gamma (PPARgamma) signaling and lipid metabolism in liver; stimulated 
      oxidative stress in the rats' liver; induced the variation of NFkappaB pathway and 
      liver inflammatory response; and caused liver fibrosis via transforming growth 
      factor beta1 (tgfbeta1). We speculated that the subcutaneously injected Phe was 
      transferred to the liver through blood circulation, which may have induced the 
      elevation of PPARgamma directly or indirectly, leading to liver steatosis. Excess 
      lipid, acting as the first hit, stimulated the second hit factors - oxidative 
      stress, inflammatory response and lipid peroxidation, and finally resulted in 
      steatohepatitis and liver fibrosis.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Guo, Jiaojiao
AU  - Guo J
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen 
      University, Xiamen, 361005, China.
FAU - Wang, Chonggang
AU  - Wang C
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen 
      University, Xiamen, 361005, China; State Key Laboratory of Marine Environmental 
      Science, Xiamen University, Xiamen, 361005, China.
FAU - Guo, Zhizhun
AU  - Guo Z
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen 
      University, Xiamen, 361005, China.
FAU - Zuo, Zhenghong
AU  - Zuo Z
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen 
      University, Xiamen, 361005, China; State Key Laboratory of Marine Environmental 
      Science, Xiamen University, Xiamen, 361005, China. Electronic address: 
      zuozhenghong@xmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180413
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenanthrenes)
RN  - 448J8E5BST (phenanthrene)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants/*toxicity
MH  - Lipid Metabolism
MH  - Lipid Peroxidation
MH  - Liver/metabolism
MH  - Male
MH  - Non-alcoholic Fatty Liver Disease/*chemically induced
MH  - Oxidative Stress
MH  - Phenanthrenes/metabolism/*toxicity
MH  - Phenotype
MH  - Rats
MH  - Signal Transduction
OTO - NOTNLM
OT  - Liver fibrosis
OT  - NFkappaB
OT  - Non-alcoholic steatohepatitis
OT  - PPARgamma
OT  - Phenanthrene
EDAT- 2018/04/16 06:00
MHDA- 2018/08/30 06:00
CRDT- 2018/04/16 06:00
PHST- 2017/11/29 00:00 [received]
PHST- 2018/03/25 00:00 [revised]
PHST- 2018/04/06 00:00 [accepted]
PHST- 2018/04/16 06:00 [pubmed]
PHST- 2018/08/30 06:00 [medline]
PHST- 2018/04/16 06:00 [entrez]
AID - S0269-7491(17)34956-4 [pii]
AID - 10.1016/j.envpol.2018.04.030 [doi]
PST - ppublish
SO  - Environ Pollut. 2018 Aug;239:261-271. doi: 10.1016/j.envpol.2018.04.030. Epub 
      2018 Apr 13.