PMID- 29657093
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 178
DP  - 2018 Sep
TI  - Advances in transformable drug delivery systems.
PG  - 546-558
LID - S0142-9612(18)30235-7 [pii]
LID - 10.1016/j.biomaterials.2018.03.056 [doi]
AB  - These years, transformable drug delivery systems (DDSs), which hold the 
      capability of changing formulation morphology and subsequent functionality at the 
      desired disease site, have shown great promise in control of spatio-temporal drug 
      delivery/release manner and enhanced treatment efficacy. Equipped with 
      controllability and design flexibility, the transformable DDSs are being 
      increasingly pursued for the development of precision drug delivery platforms for 
      biomedical applications. In this review, we describe the recently developed 
      intracelluarly and extracellularly transformable DDSs, especially associated with 
      assembly or disassociation of the original formulation units, for achieving 
      various functionalities, including prolonged retention time, inhibited 
      endocytosis and enhanced cytotoxicity. Furthermore, the different stimuli, such 
      as pH, enzyme, light, temperature, redox and mechanical force that trigger the 
      transformation process are also introduced. The future outlook and challenges are 
      discussed in the end.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Hu, Quanyin
AU  - Hu Q
AD  - Joint Department of Biomedical Engineering, University of North Carolina at 
      Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division 
      of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology 
      in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at 
      Chapel Hill, Chapel Hill, NC 27599, USA.
FAU - Chen, Qian
AU  - Chen Q
AD  - Joint Department of Biomedical Engineering, University of North Carolina at 
      Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division 
      of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology 
      in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at 
      Chapel Hill, Chapel Hill, NC 27599, USA.
FAU - Gu, Zhen
AU  - Gu Z
AD  - Joint Department of Biomedical Engineering, University of North Carolina at 
      Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division 
      of Pharmacoengineering and Molecular Pharmaceutics and Center for Nanotechnology 
      in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at 
      Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medicine, University of 
      North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic 
      address: zgu@email.unc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180405
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
SB  - IM
MH  - Animals
MH  - Drug Delivery Systems/*methods
MH  - Extracellular Space/chemistry
MH  - Humans
MH  - Intracellular Space/chemistry
MH  - Microbubbles
MH  - Nanoparticles/chemistry/ultrastructure
MH  - Neoplasms/diagnosis/pathology
OTO - NOTNLM
OT  - Cancer therapy
OT  - Drug delivery
OT  - Stimuli-responsive
OT  - Transformable formulation
EDAT- 2018/04/17 06:00
MHDA- 2019/09/04 06:00
CRDT- 2018/04/17 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/03/21 00:00 [revised]
PHST- 2018/03/31 00:00 [accepted]
PHST- 2018/04/17 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2018/04/17 06:00 [entrez]
AID - S0142-9612(18)30235-7 [pii]
AID - 10.1016/j.biomaterials.2018.03.056 [doi]
PST - ppublish
SO  - Biomaterials. 2018 Sep;178:546-558. doi: 10.1016/j.biomaterials.2018.03.056. Epub 
      2018 Apr 5.