PMID- 29657208
OWN - NLM
STAT- MEDLINE
DCOM- 20191022
LR  - 20191022
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 29
IP  - 2
DP  - 2018 Mar-Apr
TI  - Renal amyloidosis in ankylosing spondylitis: A monocentric study and review of 
      literature.
PG  - 386-391
LID - 10.4103/1319-2442.229291 [doi]
AB  - Secondary renal amyloidosis (RA) is the most common type of renal involvement in 
      ankylosing spondylitis (AS). We assessed the epidemiologic and clinico-biological 
      profile of AS patients with RA, to analyze treatment modalities and prognostic 
      aspects, and to determine predictive factors of RA during AS. This was a 
      retrospective study including 13 cases of RA among 212 cases who presented with 
      AS, during the period from 1978 to 2006. The median age of the patients at the 
      time of diagnosing AS was 47 years (range: 19-67). There were 11 males and two 
      females. RA onset was diagnosed after a mean follow-up of 144.6 months (range: 
      10-505) from the AS diagnosis. We noted erosive peripheral arthritis, lumbar 
      stiffness with bamboo spine, and coxitis in 23.1%, 76.9%, and 30.8% of cases, 
      respectively. Nephrotic syndrome was found in eight patients (61.5%). At the time 
      of diagnosing RA, six patients had renal failure. Amyloid deposits were 
      histologically proven by salivary gland biopsy in six cases (46.1%) and by renal 
      biopsy in seven cases (53.8%). Four patients received a long-course treatment 
      with colchicine but with a good outcome only in two cases. In our series, AS was 
      more severe among patients with RA. Four predictive factors of RA were 
      identified: smoking (P = 0.04), erosive peripheral arthritis (P = 0.002), bamboo 
      spine (P = 0.001), and biologic indicators of inflammation (P = 0.0001). High 
      erythrocyte sedimentation rate was identified as the only independent risk factor 
      of RA during AS (P = 0.0001). Renal function as well as urinalysis should be 
      monitored at regular intervals to detect early renal involvement during AS.
FAU - Barbouch, Samia
AU  - Barbouch S
AD  - Department of Medicine A, Charles Nicolle Hospital; Laboratory of Renal Pathology 
      - LR00S001, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Hajji, Meriam
AU  - Hajji M
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Jaziri, Fatima
AU  - Jaziri F
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Aoudia, Raja
AU  - Aoudia R
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Fellah, Eya
AU  - Fellah E
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Hedri, Hafedh
AU  - Hedri H
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Goucha, Rym
AU  - Goucha R
AD  - Department of Medicine A, Charles Nicolle Hospital; Laboratory of Renal Pathology 
      - LR00S001, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Hamida, Fethi Ben
AU  - Hamida FB
AD  - Department of Medicine A, Charles Nicolle Hospital; Laboratory of Renal Pathology 
      - LR00S001, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Taarit, Fethi Ben
AU  - Taarit FB
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Gorsane, Imen
AU  - Gorsane I
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
FAU - Abdallah, Taieb Ben
AU  - Abdallah TB
AD  - Department of Medicine A, Charles Nicolle Hospital, Tunis, Tunisia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/blood/diagnosis/*epidemiology/therapy
MH  - Arthritis/epidemiology
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Blood Sedimentation
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Kidney/pathology
MH  - Kidney Failure, Chronic/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Renal Insufficiency, Chronic/blood/diagnosis/*epidemiology/therapy
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Smoking/adverse effects/epidemiology
MH  - Spine/diagnostic imaging
MH  - Spondylitis, Ankylosing/blood/diagnosis/*epidemiology/therapy
MH  - Time Factors
MH  - Tunisia/epidemiology
MH  - Young Adult
COIS- None declared
EDAT- 2018/04/17 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/04/17 06:00
PHST- 2018/04/17 06:00 [entrez]
PHST- 2018/04/17 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2018_29_2_386_229291 [pii]
AID - 10.4103/1319-2442.229291 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2018 Mar-Apr;29(2):386-391. doi: 
      10.4103/1319-2442.229291.