PMID- 29658239
OWN - NLM
STAT- MEDLINE
DCOM- 20180815
LR  - 20220318
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 23
IP  - 1
DP  - 2017 Jan
TI  - [Gene polymorphisms of estrogen receptor alpha correlated with hypospadias in 
      children].
PG  - 61-64
AB  - OBJECTIVE: To investigate the association of the polymorphisms of the gene of 
      estrogen receptor alpha 1 (ESR1) with the risk of hypospadias in children of 
      Northeast China. METHODS: This study included 95 hypospadias patients aged 
      3.2+/-0.6 years and 105 children aged 3.1+/-0.7 years as normal controls. Using PCR 
      and gene sequencing, we determined the genotypes of the polymorphisms of ESR1 
      rs2077647 and rs6932902 in the two groups of subjects. RESULTS: The results of 
      PCR and gene sequencing showed statistically significant differences in the 
      genotype and allele frequency distribution of the polymorphisms rs2077647 (chi2 = 
      8.552) and rs6932902 (chi2 = 16.251) (P<0.05) in the hypospadias and control 
      groups. The hypospadias patients, in comparison with the normal controls, 
      exhibited a markedly higher frequency of the SNP C allele in rs2077647 (OR = 
      1.410 ［1.130－1.759］, P<0.05), but a remarkably lower frequency of the SNP G 
      allele in rs6932902 (OR = 2.263 ［1.503－3.408］, P<0.01). CONCLUSIONS: The 
      rs2077647 and rs6932902 polymorphisms of the ESR1 gene are associated with the 
      risk of hypospadias, and so is its haplotype in children in Northeast China.
FAU - Zhang, Zhi-Hui
AU  - Zhang ZH
AD  - Department of Urology, Hongqi Hospital of Mudanjiang Medical College, Mudanjiang, 
      Heilongjiang 157011, China.
FAU - Wang, Shu-Hui
AU  - Wang SH
AD  - Department of Integrated Traditional Chinese and Western Medicine, Hongqi 
      Hospital of Mudanjiang Medical College, Mudanjiang, Heilongjiang 157011, China.
FAU - Bai, Ji-Xiang
AU  - Bai JX
AD  - Department of Urology, Hongqi Hospital of Mudanjiang Medical College, Mudanjiang, 
      Heilongjiang 157011, China..
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - *Alleles
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - China
MH  - Estrogen Receptor alpha/*genetics
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Hypospadias/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Risk
OTO - NOTNLM
OT  - estrogen receptor alpha
OT  - hypospadias
OT  - single nucleotide polymorphism
EDAT- 2017/01/01 00:00
MHDA- 2018/08/16 06:00
CRDT- 2018/04/17 06:00
PHST- 2018/04/17 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2018/08/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2017 Jan;23(1):61-64.