PMID- 29658832
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20210204
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 24
IP  - 4
DP  - 2018 Apr
TI  - THE ASSOCIATIONS BETWEEN HYPOVITAMINOSIS D, HIGHER PTH LEVELS WITH BONE MINERAL 
      DENSITIES, AND RISK OF THE 10-YEAR PROBABILITY OF MAJOR OSTEOPOROTIC FRACTURES IN 
      CHINESE PATIENTS WITH T2DM.
PG  - 334-341
LID - 10.4158/EP-2017-0164 [doi]
AB  - OBJECTIVE: In the current study, we investigated the vitamin D status, and its 
      relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), 
      and the 10-year probability of fractures in Chinese patients with type 2 diabetes 
      mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs 
      at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured 
      by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D 
      (25(OH)D) and intact PTH were also quantified. The 10-year probability of 
      fracture risk (major osteoporotic fracture [MOF] and hip fracture [HF]) was 
      assessed using the fracture risk assessment tool (FRAX). RESULTS: The prevalence 
      of vitamin D deficiency was 82.3%, and the mean 25(OH)D level was 36.9 +/- 15.2 
      nmol/L. The adequate group had higher BMDs at the FN and TH and lower MOF risk 
      than the inadequate groups. Lower 25(OH)D was associated with higher PTH ( r = 
      -0.126, P<.001). PTH was negatively correlated with BMDs at 3 sites and 
      positively correlated with MOF and HF, but this relationship disappeared in the 
      adequate subgroup. Multivariate stepwise regression analysis revealed that PTH 
      was the determinant of MOF (standard beta = 0.073, P = .010) and HF (standard beta = 
      0.094, P = .004). CONCLUSION: Our results identified a significantly high rate of 
      vitamin D deficiency among Chinese patients with T2DM. PTH is an important risk 
      factor responsible for the higher 10-year probability of osteoporotic fractures 
      in diabetic patients, especially in those with lower vitamin D levels. 
      ABBREVIATIONS: AKP = alkaline phosphatase; ALB = serum albumin; BMD = bone 
      mineral density; BMI = body mass index; Ca = calcium; CKD = chronic kidney 
      disease; Cr = creatinine; FN = femoral neck; FRAX = fracture risk assessment 
      tool; HbA1c = glycated hemoglobin A1c; HF = hip fracture; L2-4 = lumbar spine; 
      MOF = major osteoporotic fracture; 25(OH)D = 25-hydroxyvitamin D; P = phosphorus; 
      PTH = parathyroid hormone; T2DM = type 2 diabetes mellitus; TH = total hip; UA = 
      uric acid.
FAU - Wang, Xiao-Feng
AU  - Wang XF
FAU - Yu, Jing-Jia
AU  - Yu JJ
FAU - Wang, Xiao-Jing
AU  - Wang XJ
FAU - Jing, Yi-Xuan
AU  - Jing YX
FAU - Sun, Li-Hao
AU  - Sun LH
FAU - Tao, Bei
AU  - Tao B
FAU - Wang, Wei-Qing
AU  - Wang WQ
FAU - Ning, Guang
AU  - Ning G
FAU - Liu, Jian-Min
AU  - Liu JM
FAU - Zhao, Hong-Yan
AU  - Zhao HY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - *Bone Density
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporotic Fractures/*etiology
MH  - Parathyroid Hormone/*blood
MH  - Probability
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*complications
EDAT- 2018/04/17 06:00
MHDA- 2018/06/15 06:00
CRDT- 2018/04/17 06:00
PHST- 2018/04/17 06:00 [entrez]
PHST- 2018/04/17 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
AID - S1530-891X(20)35604-4 [pii]
AID - 10.4158/EP-2017-0164 [doi]
PST - ppublish
SO  - Endocr Pract. 2018 Apr;24(4):334-341. doi: 10.4158/EP-2017-0164.