PMID- 29659841
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220330
IS  - 1464-3677 (Electronic)
IS  - 1353-4505 (Print)
IS  - 1353-4505 (Linking)
VI  - 30
IP  - 7
DP  - 2018 Aug 1
TI  - Incidence and mortality from adverse effects of medical treatment in the UK, 
      1990-2013: levels, trends, patterns and comparisons.
PG  - 558-564
LID - 10.1093/intqhc/mzy068 [doi]
AB  - OBJECTIVE: To present an update on incidence and mortality from adverse effects 
      (AEs) of medical treatment in the UK, its four countries and nine English regions 
      between 1990 and 2013. DESIGN: Descriptive epidemiological study on AEs of 
      medical treatment. AEs are shown as a single cause-of-injury category from the 
      Global Burden of Disease (GBD) 2013 study. DATA SOURCES: The GBD 2013 interactive 
      data visualisation tools 'Epi Visualisation' and 'GBD Compare'. OUTCOME MEASURES: 
      The means of incidence and mortality rates with 95% uncertainty intervals (UIs). 
      The estimates are age-standardised. RESULTS: Incidence rate was 175 and 176 cases 
      per 100 000 men, 173 and 174 cases per 100 000 women in 1990 and 2013, in the UK 
      (UI 170-180). The mortality from AEs declined from 1.33 deaths (UI 0.99-1.5) to 
      0.92 deaths (UI 0.75-1.2) per 100 000 individuals in the UK between 1990 and 2013 
      (30.8% change). Although mortality trends were descending in every region of the 
      UK, they varied by geography and gender. Mortality rates in Scotland, North East 
      England and West Midlands were highest. Mortality rates in South England and 
      Northern Ireland were lowest. In 2013, age-specific mortality rates were higher 
      in males in all 20 age groups compared with females. CONCLUSIONS: Despite gains 
      in reducing mortality from AEs of medical treatment in the UK between 1990 and 
      2013, the incidence of AEs remained the same. The results of this analysis 
      suggest revising healthcare policies and programmes aimed to reduce incidence of 
      AEs in the UK.
FAU - Lunevicius, Raimundas
AU  - Lunevicius R
AD  - General Surgery Department, Aintree University Hospital NHS Foundation Trust, 
      Lower Lane, Liverpool, UK.
AD  - University of Liverpool, School of Medicine, Liverpool, UK.
FAU - Haagsma, Juanita A
AU  - Haagsma JA
AD  - Erasmus MC, Erasmus University Medical Center, Rotterdam CA, The Netherlands.
AD  - Institute for Health Metrics and Evaluation, University of Washington, 2301 Fifth 
      Avenue, Seattle, WA, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Int J Qual Health Care
JT  - International journal for quality in health care : journal of the International 
      Society for Quality in Health Care
JID - 9434628
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Mortality/trends
MH  - Therapeutics/*adverse effects/*mortality
MH  - United Kingdom/epidemiology
PMC - PMC6094799
EDAT- 2018/04/17 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/04/12
CRDT- 2018/04/17 06:00
PHST- 2017/04/20 00:00 [received]
PHST- 2018/03/21 00:00 [accepted]
PHST- 2018/04/17 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/17 06:00 [entrez]
PHST- 2018/04/12 00:00 [pmc-release]
AID - 4969409 [pii]
AID - mzy068 [pii]
AID - 10.1093/intqhc/mzy068 [doi]
PST - ppublish
SO  - Int J Qual Health Care. 2018 Aug 1;30(7):558-564. doi: 10.1093/intqhc/mzy068.