PMID- 29660456
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 115
DP  - 2018 Aug
TI  - Chitosan-based hydrogels: Preparation, properties and applications.
PG  - 194-220
LID - S0141-8130(18)30010-2 [pii]
LID - 10.1016/j.ijbiomac.2018.04.034 [doi]
AB  - Chitosan (CS), the second most plentiful natural polysaccharide next to 
      cellulose, has valuable characteristics including biocompatibility, nontoxicity 
      and biodegradability. CS is broken down in the human body to innocuous products 
      (amino sugars). Hydrogels are polymeric materials with three dimensional networks 
      retaining a huge quantity of water within their structures which are of great 
      interest in biomedical/environmental applications. Usually, injectable hydrogels 
      have functional groups which are sensitive to pH, temperature or irradiation 
      stimuli. Injectable scaffolds can be formed in situ through stimuli-responsive 
      effect and they can overcome the drawback of traditional scaffolds which require 
      surgery in order to be placed on the desired tissue. The antibacterial/antifungal 
      activities of chitosan-based hydrogels and their applications in controlled drug 
      delivery/release systems, tissue engineering, preparation of injectable hydrogels 
      and water treatment (removal of heavy/toxic metals and dyes) will be described. 
      Moreover, the molecular dynamics (MD) simulation were performed on the delivery 
      of the anticancer chlorambucil (CB) drug using three silica filled polymeric 
      nanocomposites based on chitosan (CS), polylactic acid (PLA) and polyethylene 
      glycol (PEG) and it was illustrated that among three drug delivery systems 
      (DDSs), the CS nanocomposite was the most efficient DDS due to the lowest drug 
      diffusion was measured for the CS system that could lead to the most 
      sustained/controlled drug delivery.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Shariatinia, Zahra
AU  - Shariatinia Z
AD  - Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), 
      P.O. Box: 15875-4413, Tehran, Iran.. Electronic address: shariati@aut.ac.ir.
FAU - Jalali, Azin Mazloom
AU  - Jalali AM
AD  - Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), 
      P.O. Box: 15875-4413, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180413
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Hydrogels)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Anti-Infective Agents/chemistry/pharmacology
MH  - Chitosan/*chemistry/pharmacology
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Tissue Engineering
MH  - Water Purification
OTO - NOTNLM
OT  - Biomedical/environmental applications
OT  - Chitosan-based hydrogels
OT  - Molecular dynamics (MD) simulation
EDAT- 2018/04/17 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/04/17 06:00
PHST- 2018/01/01 00:00 [received]
PHST- 2018/03/18 00:00 [revised]
PHST- 2018/04/08 00:00 [accepted]
PHST- 2018/04/17 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/04/17 06:00 [entrez]
AID - S0141-8130(18)30010-2 [pii]
AID - 10.1016/j.ijbiomac.2018.04.034 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2018 Aug;115:194-220. doi: 10.1016/j.ijbiomac.2018.04.034. 
      Epub 2018 Apr 13.