PMID- 29660926
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20181202
IS  - 1875-8622 (Electronic)
IS  - 1386-0291 (Linking)
VI  - 68
IP  - 4
DP  - 2018
TI  - Abnormal rheological properties of red blood cells as a potential marker of Gulf 
      War Illness: A preliminary study.
PG  - 361-370
LID - 10.3233/CH-170262 [doi]
AB  - BACKGROUND: Veterans with Gulf War Illness (GWI) experience chronic symptoms that 
      include fatigue, pain, and cognitive impairment. This symptom cluster may be the 
      consequence of impaired tissue oxygen delivery due to red blood cell (RBC) 
      dysfunction. OBJECTIVE: The purpose of this preliminary study was to determine 
      whether the microrheological behavior of RBCs is altered in GWI. METHODS: We 
      recruited 17 cases of GWI (GWI+) and 10 age matched controls (GWI-), and examined 
      RBC deformability and aggregation via ektacytometry along with measurement of 
      complete blood counts. RESULTS: RBCs were more deformable in GWI+, as indicated 
      by higher elongation indices particularly at higher shear stress values (5.33, 
      9.49, and 16.89) when compared to GWI-. Aggregation formation, stability and 
      kinetics were similar between GWI+and GWI-. Complete blood counts were also 
      similar, with the exception of mean corpuscular hemoglobin (MCH), mean 
      corpuscular hemoglobin concentration (MCHC), and RBC distribution width (RDW) 
      which was elevated in GWI+. CONCLUSIONS: In this preliminary study, we observed 
      increased deformability along with increased MCH, MCHC and RDW in veterans with 
      GWI+, which may contribute to the symptomatology of GWI. Further research is 
      required to confirm our findings and the role of RBC microrheology in GWI.
FAU - Falvo, Michael J
AU  - Falvo MJ
AD  - War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health 
      Care System, East Orange, NJ, USA.
AD  - New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, 
      USA.
FAU - Chen, Yang
AU  - Chen Y
AD  - War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health 
      Care System, East Orange, NJ, USA.
AD  - New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, 
      USA.
FAU - Klein, Jacquelyn C
AU  - Klein JC
AD  - War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health 
      Care System, East Orange, NJ, USA.
FAU - Ndirangu, Duncan
AU  - Ndirangu D
AD  - War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health 
      Care System, East Orange, NJ, USA.
FAU - Condon, Michael R
AU  - Condon MR
AD  - New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, 
      USA.
AD  - Surgical Service, Veterans Affairs New Jersey Health Care System, East Orange, 
      NJ, USA.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
SB  - IM
MH  - Blood Cell Count/*methods
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gulf War
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rheology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Persian Gulf Syndrome
OT  - blood cell count
OT  - fatigue
OT  - hemorheology
OT  - rheology
EDAT- 2018/04/18 06:00
MHDA- 2018/06/02 06:00
CRDT- 2018/04/18 06:00
PHST- 2018/04/18 06:00 [entrez]
PHST- 2018/04/18 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
AID - CH170262 [pii]
AID - 10.3233/CH-170262 [doi]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2018;68(4):361-370. doi: 10.3233/CH-170262.