PMID- 29661832 OWN - NLM STAT- MEDLINE DCOM- 20190415 LR - 20220716 IS - 1549-5485 (Electronic) IS - 1072-0502 (Print) IS - 1072-0502 (Linking) VI - 25 IP - 5 DP - 2018 May TI - Kinase activity in the olfactory bulb is required for odor memory consolidation. PG - 198-205 LID - 10.1101/lm.046615.117 [doi] AB - Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)-a process that is closely associated with BDNF signaling. We sought to elucidate the role of neurotrophin signaling within the OB on odor memory consolidation. Male mice were trained on odor-reward associative discriminations after bilateral infusion of the kinase inhibitor K252a, or vehicle control, into the OB. K252a is a partially selective inhibitor of tyrosine kinase (Trk) receptors, including the TrkB receptor for BDNF, though it also inhibits other plasticity-related kinases such as PKC and CaMKII/IV. K252a infusion into the OB did not impair odor acquisition or short-term (2 h) memory for the learned discriminations, but significantly impaired long-term (48 h) odor memory (LTM). This LTM deficit also was associated with reduced selectivity for the conditioned odorant in a reward-seeking digging task. Infusions of K252a immediately prior to testing did not impair LTM recall. These results indicate that kinase activation in the OB is required for the consolidation of odor memory of incrementally acquired information. CI - (c) 2018 Tong et al.; Published by Cold Spring Harbor Laboratory Press. FAU - Tong, Michelle T AU - Tong MT AD - Department of Psychology, Cornell University, Ithaca, New York 14853, USA tongmi@earlham.edu. AD - Department of Psychology, Earlham College, Richmond, Indiana 47374, USA. FAU - Kim, Tae-Young P AU - Kim TP AD - Department of Psychology, Cornell University, Ithaca, New York 14853, USA. FAU - Cleland, Thomas A AU - Cleland TA AD - Department of Psychology, Cornell University, Ithaca, New York 14853, USA. LA - eng GR - R01 DC014701/DC/NIDCD NIH HHS/United States PT - Journal Article DEP - 20180416 PL - United States TA - Learn Mem JT - Learning & memory (Cold Spring Harbor, N.Y.) JID - 9435678 RN - 0 (Carbazoles) RN - 0 (Enzyme Inhibitors) RN - 0 (Indole Alkaloids) RN - 97161-97-2 (staurosporine aglycone) RN - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) SB - IM MH - Animals MH - Carbazoles/administration & dosage MH - Discrimination, Psychological MH - Enzyme Inhibitors/administration & dosage MH - Indole Alkaloids/administration & dosage MH - Male MH - Memory Consolidation/drug effects/*physiology MH - Memory, Long-Term/drug effects/*physiology MH - Mice MH - Odorants MH - Olfactory Bulb/*enzymology MH - Olfactory Perception/physiology MH - Receptor Protein-Tyrosine Kinases/antagonists & inhibitors/*physiology MH - Smell/*physiology PMC - PMC5903401 EDAT- 2018/04/18 06:00 MHDA- 2019/04/16 06:00 PMCR- 2019/05/01 CRDT- 2018/04/18 06:00 PHST- 2017/10/12 00:00 [received] PHST- 2018/02/05 00:00 [accepted] PHST- 2018/04/18 06:00 [entrez] PHST- 2018/04/18 06:00 [pubmed] PHST- 2019/04/16 06:00 [medline] PHST- 2019/05/01 00:00 [pmc-release] AID - 25/5/198 [pii] AID - LM046615Ton [pii] AID - 10.1101/lm.046615.117 [doi] PST - epublish SO - Learn Mem. 2018 Apr 16;25(5):198-205. doi: 10.1101/lm.046615.117. Print 2018 May.