PMID- 29662939
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 5
IP  - 1
DP  - 2018 Jan-Feb
TI  - LTP or LTD? Modeling the Influence of Stress on Synaptic Plasticity.
LID - 10.1523/ENEURO.0242-17.2018 [doi]
LID - ENEURO.0242-17.2018
AB  - In cognitive memory, long-term potentiation (LTP) has been shown to occur when 
      presynaptic and postsynaptic activities are highly correlated and glucocorticoid 
      concentrations are in an optimal (i.e., low normal) range. In all other 
      conditions, LTP is attenuated or even long-term depression (LTD) occurs. In this 
      paper, we focus on NMDA receptor (NMDA-R)-dependent LTP and LTD, two processes 
      involving various molecular mechanisms. To understand which of these mechanisms 
      are indispensable for explaining the experimental evidence reported in the 
      literature, we here propose a parsimonious model of NMDA-R-dependent synaptic 
      plasticity. Central to this model are two processes. First, AMPA receptor-subunit 
      trafficking; and second, glucocorticoid-dependent modifications of the 
      brain-derived neurotrophic factor (BDNF)-receptor system. In 2008, we have 
      published a core model, which contained the first process, while in the current 
      paper we present an extended model, which also includes the second process. Using 
      the extended model, we could show that stress attenuates LTP, while it enhances 
      LTD. These simulation results are in agreement with experimental findings from 
      other labs. In 2013, surprising experimental evidence showed that the GluA1 
      C-tail is unnecessary for LTP. When using our core model in its original form, 
      our simulations already predicted that there would be no requirement for the 
      GluA1 C-tail for LTP, allowing to eliminate a redundant mechanism from our model. 
      In summary, we present a mathematical model that displays reduced complexity and 
      is useful for explaining when and how LTP or LTD occurs at synapses during 
      cognitive memory formation.
FAU - Peters, Achim
AU  - Peters A
AUID- ORCID: 0000-0002-9944-7536
AD  - Medical Clinic 1, Endocrinology and Diabetes, University of Luebeck, Luebeck 
      D-23538, Germany.
FAU - Reisch, Cordula
AU  - Reisch C
AUID- ORCID: 0000-0003-1442-1474
AD  - Institut Computational Mathematics, Technical University Braunschweig, 
      Braunschweig D-38106, Germany.
FAU - Langemann, Dirk
AU  - Langemann D
AD  - Institut Computational Mathematics, Technical University Braunschweig, 
      Braunschweig D-38106, Germany.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Computer Simulation
MH  - Humans
MH  - *Long-Term Potentiation
MH  - *Long-Term Synaptic Depression
MH  - *Models, Neurological
MH  - Neurons/*physiology
MH  - Receptor, trkB/physiology
MH  - Receptors, AMPA/physiology
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Signal Transduction
MH  - *Stress, Psychological
PMC - PMC5898787
OTO - NOTNLM
OT  - cognitive memory
OT  - glucocorticoids
OT  - long-term depression
OT  - long-term potentiation
OT  - mathematical model
OT  - stress
EDAT- 2018/04/18 06:00
MHDA- 2019/01/10 06:00
PMCR- 2018/04/06
CRDT- 2018/04/18 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2018/01/15 00:00 [revised]
PHST- 2018/01/21 00:00 [accepted]
PHST- 2018/04/18 06:00 [entrez]
PHST- 2018/04/18 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2018/04/06 00:00 [pmc-release]
AID - eN-TNC-0242-17 [pii]
AID - 10.1523/ENEURO.0242-17.2018 [doi]
PST - epublish
SO  - eNeuro. 2018 Apr 6;5(1):ENEURO.0242-17.2018. doi: 10.1523/ENEURO.0242-17.2018. 
      eCollection 2018 Jan-Feb.