PMID- 29664336
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20180723
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 288
IP  - 1
DP  - 2018 Jul
TI  - Left Ventricular Myocardial Deformation on Cine MR Images: Relationship to 
      Severity of Disease and Prognosis in Light-Chain Amyloidosis.
PG  - 73-80
LID - 10.1148/radiol.2018172435 [doi]
AB  - Purpose To measure left ventricular (LV) myocardial strain with cine magnetic 
      resonance (MR) imaging and a deformable registration algorithm (DRA) and to 
      assess the prognostic value of myocardial strain in patients with light-chain 
      (AL) amyloidosis. Materials and Methods In this prospective study, 78 consecutive 
      patients with AL amyloidosis who underwent contrast material-enhanced cardiac MR 
      imaging were enrolled at West China Hospital. LV myocardial strains and late 
      gadolinium enhancement (LGE) were evaluated. Association between myocardial 
      strain and all-cause mortality was analyzed with the stepwise Cox regression 
      model. Results Global longitudinal strain (GLS) and global circumferential strain 
      (GCS) were significantly lower in the no or nonspecific LGE group compared with 
      the subendocardial LGE and transmural LGE groups (mean GLS, -10% +/- 3 [standard 
      deviation] vs -7% +/- 3 vs -4% +/- 1; P < .001) (mean GCS, -13% +/- 3 vs -11% +/- 3 vs 
      -7% +/- 2; P < .001). GLS and GCS were reduced in patients without clinical cardiac 
      amyloidosis (mean GLS, -13% +/- 3 vs -16% +/- 2; P = .005) (mean GCS, -16% +/- 1 vs 
      -19% +/- 2; P = .02). Circumferential and radial strains were impaired in basal 
      segments in accordance with the distribution of LGE. Multivariate Cox analysis 
      revealed that GCS (hazard ratio [HR] = 1.16 per 1% absolute decrease; 95% 
      confidence interval [CI]: 1.03, 1.31; P = .02) and the presence of transmural LGE 
      (HR = 1.75; 95% CI: 1.10, 2.80; P = .02) were independent predictors of all-cause 
      mortality after adjustment for LV ejection fraction, right ventricular ejection 
      fraction, LV mass index, GLS, and global radial strain. Conclusion Strain 
      parameters derived with cine MR imaging-based DRA may be a new noninvasive 
      imaging marker with which to evaluate the extent of cardiac amyloid infiltration 
      and may offer independent prognostic information for all-cause mortality in 
      patients with AL amyloidosis.
CI  - (c) RSNA, 2018 Online supplemental material is available for this article.
FAU - Wan, Ke
AU  - Wan K
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Sun, Jiayu
AU  - Sun J
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Yang, Dan
AU  - Yang D
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Liu, Hong
AU  - Liu H
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Wang, Jie
AU  - Wang J
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Cheng, Wei
AU  - Cheng W
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Zhang, Qing
AU  - Zhang Q
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Zeng, Zhi
AU  - Zeng Z
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Zhang, Tianjing
AU  - Zhang T
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Greiser, Andreas
AU  - Greiser A
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Jolly, Marie-Pierre
AU  - Jolly MP
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Han, Yuchi
AU  - Han Y
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
FAU - Chen, Yucheng
AU  - Chen Y
AUID- ORCID: 0000-0002-0601-8039
AD  - From the Departments of Cardiology (K.W., D.Y., H.L., J.W., Q.Z., Z.Z., Y.C.) and 
      Radiology (J.S., W.C.), West China Hospital, Sichuan University, Guoxue Xiang No. 
      37, Chengdu, Sichuan 610041, P. R. China; Siemens Healthineers Northeast Asia 
      Collaboration, Beijing, China (T.Z.); Siemens Healthineers, Erlangen, Germany 
      (A.G.); Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ 
      (M.P.J.); and Department of Medicine, Cardiovascular Division, University of 
      Pennsylvania, Philadelphia, Pa (Y.H.).
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180417
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloidosis/*complications/diagnostic imaging
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Ventricular Dysfunction, Left/*complications/*diagnostic imaging/physiopathology
EDAT- 2018/04/18 06:00
MHDA- 2018/07/24 06:00
CRDT- 2018/04/18 06:00
PHST- 2018/04/18 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2018/04/18 06:00 [entrez]
AID - 10.1148/radiol.2018172435 [doi]
PST - ppublish
SO  - Radiology. 2018 Jul;288(1):73-80. doi: 10.1148/radiol.2018172435. Epub 2018 Apr 
      17.