PMID- 29665123
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20191210
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 45
IP  - 7
DP  - 2018 Jul
TI  - Pilot study on the correlation between dermoscopic patterns and fluorescence in 
      situ hybridization findings using whole-slide digital imaging for acral volar 
      melanocytic lesions.
PG  - 830-836
LID - 10.1111/1346-8138.14324 [doi]
AB  - Dermoscopic evaluation of acral volar skin is helpful in differentiating 
      malignant melanomas (MM) from benign melanocytic nevi. However, histological 
      diagnosis remains difficult because sufficient evidence of histopathological 
      changes to establish a diagnosis of MM are not easily obtained. The aim of the 
      present study was to evaluate the effective use of fluorescence in situ 
      hybridization (FISH) in the diagnosis of acral volar melanocytic lesions, and to 
      determine whether acral volar melanocytic lesions show characteristic molecular 
      biological features of malignant melanoma via FISH. We classified acral volar 
      melanocytic lesions showing junctional findings into three groups: (A) parallel 
      ridge pattern (PRP) on dermoscopic examination with melanoma in situ; (B) PRP 
      with insufficient melanocyte proliferation and atypia to diagnose malignant 
      melanoma using hematoxylin-eosin staining; and (C) junctional nevi. We performed 
      FISH analysis using the same tissue section that was used for hematoxylin-eosin 
      staining. FISH positivity was seen in 80% (4/5) of the group A sections, and in 
      80% (4/5) of the group B sections. One case in group C was only 0.3% over the 
      established criteria line (63.3% > 63% in RREB1). Our results suggest that FISH 
      using whole-slide digital imaging may be useful in the diagnosis of early in situ 
      MM when a typical PRP is observed in an acral volar skin lesion with 
      non-diagnostic histopathology.
CI  - (c) 2018 Japanese Dermatological Association.
FAU - Ogata, Dai
AU  - Ogata D
AUID- ORCID: 0000-0002-1335-7100
AD  - Department of Dermatology, Saitama Medical University, Irumagun, Japan.
FAU - Arai, Eiichi
AU  - Arai E
AD  - Department of Pathology, Saitama Medical University, International Medical 
      Center, Hidaka, Japan.
FAU - Goto, Yoshiya
AU  - Goto Y
AD  - Department of Pathology, Saitama Medical University, International Medical 
      Center, Hidaka, Japan.
FAU - Tsuchida, Tetsuya
AU  - Tsuchida T
AD  - Department of Dermatology, Saitama Medical University, Irumagun, Japan.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180417
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Proliferation
MH  - Dermoscopy/*methods
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanocytes/pathology
MH  - Melanoma/*diagnostic imaging/pathology
MH  - Middle Aged
MH  - Nevus, Pigmented/*diagnostic imaging/pathology
MH  - Pilot Projects
MH  - Skin/cytology/diagnostic imaging/pathology
OTO - NOTNLM
OT  - acral lentiginous melanoma in situ
OT  - fluorescence in situ hybridization
OT  - nevus
OT  - parallel ridge pattern
OT  - virtual slide
EDAT- 2018/04/18 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/04/18 06:00
PHST- 2018/01/30 00:00 [received]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/04/18 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/04/18 06:00 [entrez]
AID - 10.1111/1346-8138.14324 [doi]
PST - ppublish
SO  - J Dermatol. 2018 Jul;45(7):830-836. doi: 10.1111/1346-8138.14324. Epub 2018 Apr 
      17.