PMID- 2966629
OWN - NLM
STAT- MEDLINE
DCOM- 19880602
LR  - 20131121
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 38
IP  - 1
DP  - 1988 Jan
TI  - Immunopharmacological actions of the new antiallergic drug butyl 
      3'-(1H-tetrazol-5-yl)oxanilate. 1st communication: effects on type I to type IV 
      allergic reactions in animal models.
PG  - 70-4
AB  - The effects of butyl 3'-(1H-tetrazol-5-yl)oxanilate (WP-833), a new antiallergic 
      drug, on type I to type IV allergic reactions were investigated by employing 
      various animal models. WP-833 (i.v. and p.o.) dose-dependently inhibited 
      homologous or heterologous passive cutaneous anaphylaxis (PCA) mediated by rat or 
      mouse immunoglobulin E (IgE) in rats. Homologous PCA caused by guinea pig IgE was 
      also inhibited by WP-833. In addition, WP-833 had inhibitory actions upon 
      homologous PCA induced by rat or guinea pig IgG. However, WP-833 showed no 
      inhibition of rat skin reactions caused by histamine, serotonin and bradykinin, 
      contrasting with the inhibition of prostaglandin E1-induced skin reaction. 
      Furthermore, both adrenalectomy and propranolol treatment exerted no influences 
      on the inhibition of IgE-mediated homologous PCA in rats by WP-833. In contrast 
      to above findings demonstrating that WP-833 clearly inhibited type I allergic 
      reaction, systemic Forssman shock in guinea pigs and reversed cutaneous 
      anaphylaxis in rats (type II), passive Arthus reaction in rats (type III), and 
      contact dermatitis and tuberculin reaction in mice (type IV) were unaffected by 
      WP-833 even in higher doses than in those capable of completely inhibiting type I 
      allergic reaction.
FAU - Yanagihara, Y
AU  - Yanagihara Y
AD  - Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, 
      Japan.
FAU - Abe, T
AU  - Abe T
FAU - Edanami, K
AU  - Edanami K
FAU - Agata, M
AU  - Agata M
FAU - Kuroda, T
AU  - Kuroda T
FAU - Shida, T
AU  - Shida T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Azoles)
RN  - 0 (Dinitrophenols)
RN  - 0 (Tetrazoles)
RN  - 0 (butyl 3-(1H-tetrazol-5-yl)oxanilate)
RN  - 9013-60-9 (Forssman Antigen)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Adrenalectomy
MH  - Animals
MH  - Antibody Formation/drug effects
MH  - Arthus Reaction/immunology
MH  - Azoles/*pharmacology
MH  - Dinitrophenols/immunology
MH  - Forssman Antigen/analysis
MH  - Guinea Pigs
MH  - Hypersensitivity/*drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Propranolol/pharmacology
MH  - Rabbits
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Skin Tests
MH  - Tetrazoles/*pharmacology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Arzneimittelforschung. 1988 Jan;38(1):70-4.