PMID- 2966663
OWN - NLM
STAT- MEDLINE
DCOM- 19880613
LR  - 20190720
IS  - 0008-4212 (Print)
IS  - 0008-4212 (Linking)
VI  - 65
IP  - 11
DP  - 1987 Nov
TI  - Interactions of cholecystokinin, beta-endorphin, and their antagonists on passive 
      avoidance behavior in rats.
PG  - 2260-4
AB  - The effects of cholecystokinin octapeptide (CCK-8), cholecystokinin tetrapeptide 
      amide (CCK-4), beta-endorphin, proglumide, and naloxone on passive avoidance 
      behavior were studied in rats. Intracerebroventricular (i.c.v.) injection of 
      beta-endorphin (1-10 micrograms) had no significant influence on the latency of 
      the avoidance response in intact rats. Also, beta-endorphin (0.05-5 micrograms, 
      i.c.v.) did not affect the response in rats treated with electroconvulsive shock 
      (ECS). The preventive effect of CCK-8 (0.1-1.0 micrograms, i.c.v.) on ECS-induced 
      amnesia was partly antagonized by beta-endorphin (0.05-10 micrograms, i.c.v.). 
      Intraperitoneal (i.p.) injection of naloxone (1-10 mg/kg) could not prevent 
      ECS-induced amnesia, but continuous subcutaneous infusion of this drug (2 mg/day, 
      7 days) completely abolished the amnesia. Naloxone (1 and 10 mg/kg, i.p.) also 
      partly antagonized amnesia induced by proglumide (1 and 10 micrograms, i.c.v.) 
      and prevented it when induced by CCK-4 (5 and 10 micrograms, i.c.v.). The results 
      indicate the facilitating action of naloxone and the inhibitory effect of 
      beta-endorphin on memory, suggesting that the endogenous opiate systems are 
      involved in some way in the memory processes.
FAU - Itoh, S
AU  - Itoh S
AD  - Shionogi Research Laboratories, Osaka, Japan.
FAU - Katsuura, G
AU  - Katsuura G
FAU - Takashima, A
AU  - Takashima A
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 36B82AMQ7N (Naloxone)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 9011-97-6 (Cholecystokinin)
RN  - EPL8W5565D (Proglumide)
SB  - IM
MH  - Amnesia/chemically induced
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Cholecystokinin/antagonists & inhibitors/*pharmacology
MH  - Electroshock
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/administration & dosage/pharmacology
MH  - Proglumide/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - beta-Endorphin/antagonists & inhibitors/*pharmacology
EDAT- 1987/11/01 00:00
MHDA- 1987/11/01 00:01
CRDT- 1987/11/01 00:00
PHST- 1987/11/01 00:00 [pubmed]
PHST- 1987/11/01 00:01 [medline]
PHST- 1987/11/01 00:00 [entrez]
AID - 10.1139/y87-357 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 1987 Nov;65(11):2260-4. doi: 10.1139/y87-357.