PMID- 29666640
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2018
DP  - 2018
TI  - Investigating the Interactive Effects of Sex Steroid Hormones and Brain-Derived 
      Neurotrophic Factor during Adolescence on Hippocampal NMDA Receptor Expression.
PG  - 7231915
LID - 10.1155/2018/7231915 [doi]
LID - 7231915
AB  - Sex steroid hormones have neuroprotective properties which may be mediated by 
      brain-derived neurotrophic factor (BDNF). This study sought to determine the 
      interactive effects of preadolescent hormone manipulation and BDNF heterozygosity 
      ((+/-)) on hippocampal NMDA-R expression. Wild-type and BDNF(+/-) mice were 
      gonadectomised, and females received either 17beta-estradiol or progesterone 
      treatment, while males received either testosterone or dihydrotestosterone (DHT) 
      treatment. Dorsal (DHP) and ventral hippocampus (VHP) were dissected, and protein 
      expression of GluN1, GluN2A, GluN2B, and PSD-95 was assessed by Western blot 
      analysis. Significant genotype x OVX interactions were found for GluN1 and GluN2 
      expression within the DHP of female mice, suggesting modulation of select NMDA-R 
      levels by female sex hormones is mediated by BDNF. Furthermore, within the DHP 
      BDNF(+/-) mice show a hypersensitive response to hormone treatment on GluN2 
      expression which may result from upstream alterations in TrkB phosphorylation. In 
      contrast to the DHP, the VHP showed no effects of hormone manipulation but 
      significant effects of genotype on NMDA-R expression. Castration had no effect on 
      NMDA-R expression; however, androgen treatment had selective effects on GluN2B. 
      These data show case distinct, interactive roles for sex steroid hormones and 
      BDNF in the regulation of NMDA-R expression that are dependent on dorsal versus 
      ventral hippocampal region.
FAU - McCarthny, Cushla R
AU  - McCarthny CR
AD  - Department of Psychiatry, School of Clinical Sciences, Monash Medical Centre, 
      Monash University, Clayton, VIC, Australia.
FAU - Du, Xin
AU  - Du X
AD  - Department of Psychiatry, School of Clinical Sciences, Monash Medical Centre, 
      Monash University, Clayton, VIC, Australia.
AD  - The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 
      Parkville, VIC, Australia.
FAU - Wu, YeeWen Candace
AU  - Wu YC
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, USA.
FAU - Hill, Rachel A
AU  - Hill RA
AUID- ORCID: 0000-0001-6111-355X
AD  - Department of Psychiatry, School of Clinical Sciences, Monash Medical Centre, 
      Monash University, Clayton, VIC, Australia.
AD  - The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 
      Parkville, VIC, Australia.
LA  - eng
PT  - Journal Article
DEP - 20180131
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC5831834
EDAT- 2018/04/19 06:00
MHDA- 2018/04/19 06:01
PMCR- 2018/01/31
CRDT- 2018/04/19 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/10/05 00:00 [revised]
PHST- 2017/10/19 00:00 [accepted]
PHST- 2018/04/19 06:00 [entrez]
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2018/04/19 06:01 [medline]
PHST- 2018/01/31 00:00 [pmc-release]
AID - 10.1155/2018/7231915 [doi]
PST - epublish
SO  - Int J Endocrinol. 2018 Jan 31;2018:7231915. doi: 10.1155/2018/7231915. 
      eCollection 2018.