PMID- 29667101
OWN - NLM
STAT- MEDLINE
DCOM- 20190110
LR  - 20190110
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 37
IP  - 8
DP  - 2018 Aug
TI  - Clinical features, risk factors, and outcomes of patients with interstitial 
      pneumonia with autoimmune features: a population-based study.
PG  - 2125-2132
LID - 10.1007/s10067-018-4111-5 [doi]
AB  - To investigate the clinical features, risk factors and outcomes of patients with 
      interstitial pneumonia with autoimmune features (IPAF). A total of 1429 patients 
      with idiopathic interstitial pneumonia (IIP) and undifferentiated connective 
      tissue disease-associated interstitial lung disease (UCTD-ILD) were screened to 
      identify patients who met IPAF criteria. Clinical, serological, and morphological 
      features of patients with IPAF were characterized. Outcomes between patients with 
      IPAF, UCTD-ILD, and IIP who were divided into idiopathic pulmonary fibrosis (IPF) 
      and non-IPF groups were compared using survival as an endpoint. Patients with 
      IPAF were much common in young female and had lower percentage of ever smoking 
      and a significantly shorter survival than those with non-IPAF (P < 0.001). 
      Subgroup analysis revealed that IPAF cohort survival was worse than that in 
      non-IPF (P < 0.001), but better than that in IPF (P < 0.001). In IPAF cohort, the 
      most common systemic symptom and serological abnormality were Raynaud's 
      phenomenon (12.9%) and ANA >/= 1:320 (49.2%); the most frequent high-resolution 
      computed tomography (HRCT) pattern was nonspecific interstitial pneumonia (NSIP) 
      (61.6%). Multivariate analysis indicated that several factors including age, 
      smoking history, organizing pneumonia (OP) pattern in HRCT, and anti-RNP 
      positivity were independently associated with significantly worse survival. IPAF 
      had the distinct clinical features and outcomes compared with other groups of 
      ILD. Additional studies should be needed to explore the underlying autoimmune 
      mechanism and to determine risk stratification in future clinical research.
FAU - Dai, Jinghong
AU  - Dai J
AD  - Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, 
      China.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, 
      China.
FAU - Yan, Xin
AU  - Yan X
AD  - Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, 
      China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, 
      China.
FAU - Zhou, Kefeng
AU  - Zhou K
AD  - Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - He, Jian
AU  - He J
AD  - Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Meng, Fanqing
AU  - Meng F
AD  - Department of Pathology, The Affiliated Drum Tower Hospital of Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Xu, Siyi
AU  - Xu S
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, Jiangsu, China.
FAU - Liang, Geyu
AU  - Liang G
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing, 210009, Jiangsu, China.
FAU - Cai, Hourong
AU  - Cai H
AD  - Department of Respiratory Medicine, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, 
      China. caihourong2013@163.com.
LA  - eng
GR  - 81570058/the National Natural Science Foundation of China/
GR  - ZDRCA2016058/Jiangsu Provincial Medical Talent/
GR  - BE2017604/Jiangsu Social Development Project/
PT  - Journal Article
DEP - 20180418
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Age Factors
MH  - Aged
MH  - *Autoimmune Diseases/blood/complications/drug therapy/pathology
MH  - Connective Tissue Diseases/pathology
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/blood/complications/drug therapy/pathology
MH  - Immunosuppressive Agents/therapeutic use
MH  - *Lung Diseases, Interstitial/blood/complications/drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Smoking/epidemiology
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Idiopathic interstitial pneumonia
OT  - Interstitial pneumonia with autoimmune features
OT  - Outcome
OT  - Risk factor
OT  - Undifferentiated connective tissue disease
EDAT- 2018/04/19 06:00
MHDA- 2019/01/11 06:00
CRDT- 2018/04/19 06:00
PHST- 2018/01/19 00:00 [received]
PHST- 2018/04/10 00:00 [accepted]
PHST- 2018/03/21 00:00 [revised]
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2019/01/11 06:00 [medline]
PHST- 2018/04/19 06:00 [entrez]
AID - 10.1007/s10067-018-4111-5 [pii]
AID - 10.1007/s10067-018-4111-5 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2018 Aug;37(8):2125-2132. doi: 10.1007/s10067-018-4111-5. Epub 
      2018 Apr 18.