PMID- 29668128
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20181023
IS  - 2590-7379 (Electronic)
IS  - 0120-4157 (Linking)
VI  - 38
IP  - 1
DP  - 2018 Mar 15
TI  - Tuberculosis associated with tumor necrosis factor-alpha antagonists, case 
      description and analysis of reported cases in Colombia.
PG  - 7-16
LID - 10.7705/biomedica.v38i0.3273 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important fundamental cytokine during the 
      immune response against cancer and infections such as tuberculosis. This molecule 
      also plays a key pathogenic role in complex and difficult-to-treat diseases such 
      as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and 
      ulcerative colitis. The treatment of these diseases frequently needs TNF-alpha 
      antagonists, which has been related to an increased risk of developing 
      tuberculosis, mycoses, and other severe infections.We report the case of a 
      68-year-old man with Crohn's disease, who developed  disseminated tuberculosis 
      due to anti-TNF-alpha immunosuppressive therapy. The diagnosis was based on the 
      histopathological findings and molecular biology assays.We discuss the clinical 
      presentation and workup of this case, and we present a comparative analysis of 
      tuberculosis cases associated with anti-TNF-alpha reported in Colombia during the 
      last 10 years emphasizing on the diagnosis and treatment of latent tuberculosis.
FAU - Galvis, Leandro
AU  - Galvis L
AD  - Laboratorio de Patologia, Clinica San Jose, San Jose de Cucuta, Colombia. 
      lgalvism@hotmail.com.
FAU - Sanchez, Angel Y
AU  - Sanchez AY
FAU - Jurado, Leonardo F
AU  - Jurado LF
FAU - Murcia, Martha I
AU  - Murcia MI
LA  - eng
PT  - Journal Article
DEP - 20180315
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Arthritis, Rheumatoid/*complications
MH  - Colombia
MH  - Crohn Disease/*drug therapy
MH  - Humans
MH  - Immunosuppressive Agents/*adverse effects/chemistry
MH  - Male
MH  - Spondylitis, Ankylosing
MH  - Tuberculosis/*complications
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
OTO - NOTNLM
OT  - Colombia
OT  - Cronh's disease
OT  - Mycobacterium tuberculosis
OT  - diagnosis
OT  - latent tuberculosis
OT  - risk factor
OT  - tuberculosis
OT  - tumor necrosis factor-alpha
EDAT- 2018/04/19 06:00
MHDA- 2018/07/17 06:00
CRDT- 2018/04/19 06:00
PHST- 2016/03/30 00:00 [received]
PHST- 2016/12/23 00:00 [revised]
PHST- 2018/04/19 06:00 [entrez]
PHST- 2018/04/19 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
AID - 10.7705/biomedica.v38i0.3273 [doi]
PST - epublish
SO  - Biomedica. 2018 Mar 15;38(1):7-16. doi: 10.7705/biomedica.v38i0.3273.